Publications

2019

von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E. Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. J Exp Med. 2019 May 24. pii: jem.20181762. doi: 10.1084/jem.20181762. [Project A03]

David Illig, Marta Navratil, Jadranka Kelečić, Raffaele Conca, Iva Hojsak, Oleg Jadrešin, Marijana Ćorić, Jurica Vuković, Meino Rohlfs, Sebastian Hollizeck, Jens Bohne, Christoph Klein, Daniel Kotlarz. Alternative Splicing Rescues Loss of Common Gamma Chain Function and Results in IL-21R-like Deficiency. J Clin Immunol. 2019 Feb;39(2):207-215. doi: 10.1007/s10875-019-00606-7. [Project A05]

Markus Zwick, Thomas Ulas, Yi-Li Cho, Christine Ried, Leonie Grosse, Charlotte Simon, Caroline Bernhard, Dirk H. Busch, Joachim L. Schultze, Veit R. Buchholz, Susanne Stutte, Thomas Brocker. Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cell. Front Immunol. 2019 Feb 12;10:222. DOI: https://doi.org/10.1101/374652 [Project B03 & B09]

Li Y, Führer M, Bahrami E, Socha P, Klaudel-Dreszler M, Bouzidi A, Liu Y, Lehle AS, Magg T, Hollizeck S, Rohlfs M, Conca R, Field M, Warner N, Mordechai S, Shteyer E, Turner D, Boukari R, Belbouab R, Walz C, Gaidt MM, Hornung V, Baumann B, Pannicke U, Al Idrissi E, Ali Alghamdi H, Sepulveda FE, Gil M, de Saint Basile G, Hönig M, Koletzko S, Muise AM, Snapper SB, Schwarz K, Klein C, Kotlarz D. Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases. PNAS. 2019 Jan 15;116(3):970-975. doi: 10.1073/pnas.1813582116. [Project A05]

Ogrinc Wagner A, Friedrich V, Barthels C, Marconi P, Blutke A, Brombacher F, Brocker T. Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis. PLoS One. 2019 Jan 17;14(1):e0210998. doi: 10.1371/journal.pone.0210998. [Project B03]

Tomoyoshi Yamano, Jan Dobeš, Matouš Vobořil, Madlen Steinert, Tomáš Brabec, Natalia Ziętara, Martina Dobešová, Caspar Ohnmacht, Martti Laan, Part Peterson, Vladimir Benes, Radislav Sedláček, Rikinari Hanayama, Michal Kolář, Ludger Klein, Dominik Filipp. Aire-expressing ILC3-like cells in the lymph node display potent APC features. Journal of Experimental Medicine Mar 2019, jem.20181430; DOI: 10.1084/jem.20181430 [Project A01]

Julia Matthias, Julia Maul, Rebecca Noster, Hanna Meinl, Ying-Yin Chao, Heiko Gerstenberg, Florian Jeschke, Gilles Gasparoni, Anna Welle, Jörn Walter, Karl Nordström, Klaus Eberhardt, Dennis Renisch, Sainitin Donakonda, Percy Knolle, Dominik Soll, Stephan Grabbe, Natalie Garzorz-Stark, Kilian Eyerich, Tilo Biedermann, Dirk Baumjohann, Christina E. Zielinski. Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment. Science Translational Medicine. 20 Feb 2019; 11:480. DOI: 10.1126/scitranslmed.aau0683 [Project B10 & B12]

Lehle AS, Farin HF, Marquardt B, Michels BE, Magg T, Li Y, Liu Y, Ghalandary M, Lammens K, Hollizeck S, Rohlfs M, Hauck F, Conca R, Walz C, Weiss B, Lev A, Simon AJ, Groß O, Gaidt MM, Hornung V, Clevers H, Yazbeck N, Hanna-Wakim R, Shouval DS, Warner N, Somech R, Muise AM, Snapper SB, Bufler P, Koletzko S, Klein C, Kotlarz D. Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency. Gastroenterology. 2019 Jan;156(1):275-278. doi: 10.1053/j.gastro.2018.09.041. [Project A05]

Ludger Klein, Ellen A. Robey, Chyi-Song Hsieh. Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation. Nature Reviews Immunology 19(1): 7-18. DOI: 10.1038/s41577-018-0083-6 [Project A01]