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Publications

2019

Hartjes, L., Ruland, J. (2019). CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis. Frontiers in Immunology, March 2019,10,419.https://doi.org/10.3389/fimmu.2019.00419   [Project B01]

Tavernier SJ, Athanasopoulos V, Verloo P, Behrens G, Staal J, Bogaert DJ, Naesens L, De Bruyne M, Van Gassen S, Parthoens E, Ellyard J, Cappello J, Morris LX, Van Gorp H, Van Isterdael G, Saeys Y, Lamkanfi M, Schelstraete P, Dehoorne J, Bordon V, Van Coster R, Lambrecht BN, Menten B, Beyaert R, Vinuesa CG, Heissmeyer V, Dullaers M, Haerynck F. A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation. Nat Commun. 2019 Oct 21;10(1):4779. doi: 10.1038/s41467-019-12704-6. [Project A03]

Gehring, T., Erdmann, T., Rahm, M., Grass, C., Flatley, A., O'Neill, T.J., Woods, S., Meininger, I., Karayel, O., Kutzner, K., Grau, M., Shinohara, H., Lammens, K., Feederle, F., Hauck, S.M., Lenz, G., and Krappmann, D. (2019). MALT1 phosphorylation controls activation of T lymphocytes and survival of ABC-DLBCL tumor cells. Cell reports, 29: 873–888. [Projects A04 & B02]

Käshammer L, Saathoff JH, Lammens K, Gut F, Bartho J, Alt A, Kessler B, Hopfner KP. Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex. Mol Cell. 2019 Aug 26. pii: S1097-2765(19). [Project B02]

Marie-Kristin Raulf, Timo Johannssen, Svea Matthiesen, Konstantin Neumann, Severin Hachenberg, Sabine Mayer-Lambertz, Fridolin Steinbeis, Jan Hegermann, Peter H. Seeberger, Wolfgang Baumgärtner, Christina Strube, Jürgen Ruland and Bernd Lepenies. The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development Cell Reports. 28, 30–38 July 2, 2019. https://doi.org/10.1016/j.celrep.2019.06.015 [Project B01]

Palit S, Heuser C, de Almeida GP, Theis FJ, Zielinski CE. Meeting the Challenges of High-Dimensional Single-Cell Data Analysis in Immunology. Front Immunol. 2019 Jul 3;10:1515. doi: 10.3389/fimmu.2019.01515. [Project B10]

Julia Matthias, Christina E. ZielinskiShaping the diversity of Th2 cell responses in epithelial tissues and its potential for allergy treatment. Eur J Immunol. 2019 Jul 5. doi: 10.1002/eji.201848011 [Project B10]

Rosenbaum, M., Gewies, A., Pechloff, K., Heuser, C., Engleitner, T., Gehring, T., Hartjes, L., Krebs, S., Krappmann, D., Kriegsmann, M., Weichert, W., Rad, R., Kurts, C., and Ruland, J. (2019). Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat Commun. 2019 May 28;10(1):2352. doi: 10.1038/s41467-019-10203-2. [Projects B01 & A04]

Andrea Musumeci, Konstantin Lutz, Elena Winheim and Anne Barbara Krug. What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity. Front Immunol. 29 May 2019; 10: 1222. doi: https://doi.org/10.3389/fimmu.2019.01222 [Project A06]

von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E. Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. J Exp Med. 2019 May 24. pii: jem.20181762. doi: 10.1084/jem.20181762. [Project A03]

Cho, J.J., Xu, Z., Parthasarathy, U., Drashansky, T.T., Helm, E.Y., Zuniga, A.N., Lorentsen, K.J., Mansouri, S., Cho, J.Y., Edelmann, M.J., Duong, D.M., Gehring, T., Seeholzer, T., Krappmann, D., Uddin, M.N., Califano, D., Wang, R.L., Jin, L., Li, H., Lv, D., Zhou, D., Zhou, L., and Avram, D. (2019). Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Nat Commun. 2019 Feb 11;10(1):701. doi: 10.1038/s41467-019-08605-3. [Project A04]

David Illig, Marta Navratil, Jadranka Kelečić, Raffaele Conca, Iva Hojsak, Oleg Jadrešin, Marijana Ćorić, Jurica Vuković, Meino Rohlfs, Sebastian Hollizeck, Jens Bohne, Christoph Klein, Daniel Kotlarz. Alternative Splicing Rescues Loss of Common Gamma Chain Function and Results in IL-21R-like Deficiency. J Clin Immunol. 2019 Feb;39(2):207-215. doi: 10.1007/s10875-019-00606-7. [Project A05]

Markus Zwick, Thomas Ulas, Yi-Li Cho, Christine Ried, Leonie Grosse, Charlotte Simon, Caroline Bernhard, Dirk H. Busch, Joachim L. Schultze, Veit R. Buchholz, Susanne Stutte, Thomas Brocker. Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cell. Front Immunol. 2019 Feb 12;10:222. DOI: https://doi.org/10.1101/374652 [Projects B03 & B09]

Li Y, Führer M, Bahrami E, Socha P, Klaudel-Dreszler M, Bouzidi A, Liu Y, Lehle AS, Magg T, Hollizeck S, Rohlfs M, Conca R, Field M, Warner N, Mordechai S, Shteyer E, Turner D, Boukari R, Belbouab R, Walz C, Gaidt MM, Hornung V, Baumann B, Pannicke U, Al Idrissi E, Ali Alghamdi H, Sepulveda FE, Gil M, de Saint Basile G, Hönig M, Koletzko S, Muise AM, Snapper SB, Schwarz K, Klein C, Kotlarz DHuman RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases. PNAS. 2019 Jan 15;116(3):970-975. doi: 10.1073/pnas.1813582116. [Project A05]

Ogrinc Wagner A, Friedrich V, Barthels C, Marconi P, Blutke A, Brombacher F, Brocker T. Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis. PLoS One. 2019 Jan 17;14(1):e0210998. doi: 10.1371/journal.pone.0210998. [Project B03]

Tomoyoshi Yamano, Jan Dobeš, Matouš Vobořil, Madlen Steinert, Tomáš Brabec, Natalia Ziętara, Martina Dobešová, Caspar Ohnmacht, Martti Laan, Part Peterson, Vladimir Benes, Radislav Sedláček, Rikinari Hanayama, Michal Kolář, Ludger Klein, Dominik Filipp. Aire-expressing ILC3-like cells in the lymph node display potent APC features. Journal of Experimental Medicine Mar 2019, jem.20181430; DOI: 10.1084/jem.20181430 [Project A01]

Julia Matthias, Julia Maul, Rebecca Noster, Hanna Meinl, Ying-Yin Chao, Heiko Gerstenberg, Florian Jeschke, Gilles Gasparoni, Anna Welle, Jörn Walter, Karl Nordström, Klaus Eberhardt, Dennis Renisch, Sainitin Donakonda, Percy Knolle, Dominik Soll, Stephan Grabbe, Natalie Garzorz-Stark, Kilian Eyerich, Tilo Biedermann, Dirk Baumjohann, Christina E. Zielinski. Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment. Science Translational Medicine. 20 Feb 2019; 11:480. DOI: 10.1126/scitranslmed.aau0683 [Projects B10 & B12]

Lehle AS, Farin HF, Marquardt B, Michels BE, Magg T, Li Y, Liu Y, Ghalandary M, Lammens K, Hollizeck S, Rohlfs M, Hauck F, Conca R, Walz C, Weiss B, Lev A, Simon AJ, Groß O, Gaidt MM, Hornung V, Clevers H, Yazbeck N, Hanna-Wakim R, Shouval DS, Warner N, Somech R, Muise AM, Snapper SB, Bufler P, Koletzko S, Klein C, Kotlarz DIntestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency. Gastroenterology. 2019 Jan;156(1):275-278. doi: 10.1053/j.gastro.2018.09.041. [Projects A05 & B02]

Kai Li, Konstantin Neumann, Vikas Duhand, Sukumar Naminenie, Anne Louise Hansen, Tim Wartewig, Zsuzsanna Kurgyisa, Christian K. Holm, Mathias Heikenwalder, Karl S. Lang, Jürgen Ruland. The uric acid crystal receptor Clec12A potentiates type I interferon responses. PNAS, September 10, 2019, vol. 116, no. 37 https://www.pnas.org/cgi/doi/10.1073/pnas.1821351116 [Project B01]

Ludger Klein, Ellen A. Robey, Chyi-Song Hsieh. Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation. Nature Reviews Immunology 19(1): 7-18. DOI: 10.1038/s41577-018-0083-6 [Project A01]


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