Publications

Schmidt H, Raj T, O'Neill TJ, Muschaweckh A, Giesert F, Negraschus A, Hoefig KP, Behrens G, Esser L, Baumann C, Feederle R, Plaza-Sirvent C, Geerlof A, Gewies A, Isay SE, Ruland J, Schmitz I, Wurst W, Korn T, Krappmann D, Heissmeyer V (2023 Nov 28) Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity. Proc Natl Acad Sci U S A. 120(48):e2309205120. doi: 10.1073/pnas.2309205120. (Projects A03, A04, B01, B06)

Maike Becker, Sini S. Joseph, Francisco Garcia-Carrizo, Robby Z. Tom, Daria Opaleva, Isabelle Serr, Matthias H.Tschöp, Tim J. Schulz, Susanna M. Hofmann, Carolin Daniel (2023 Sep 20) Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration. Cell Metabolism 35:1-16. https://doi.org/10.1016/j.cmet.2023.08.010 (Project B11)

Guo L, Salian S, Xue JY, Rath N, Rousseau J, Kim H, Ehresmann S, Moosa S, Nakagawa N, Kuroda H, Clayton-Smith J, Wang J, Wang Z, Banka S, Jackson A, Zhang YM, Wei ZJ, Hüning I, Brunet T, Ohashi H, Thomas MF, Bupp C, Miyake N, Matsumoto N, Mendoza-Londono R, Costain G, Hahn G, Di Donato N, Yigit G, Yamada T, Nishimura G, Ansel KM, Wollnik B, Hrabě de Angelis M, Mégarbané A, Rosenfeld JA, Heissmeyer V, Ikegawa S, Campeau PM (2023 Jul 6) Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans. Am J Hum Genet. 110(7):1068-1085. doi: 10.1016/j.ajhg.2023.06.001.(Project A03)

Leoni C, Bataclan M, Ito-Kureha T, Heissmeyer V, Monticelli S (2023 Jun 29) The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells. Nat Commun. 14(1):3862. doi: 10.1038/s41467-023-39614-y. (Project A03)

Lisa Rausch, Lavinia Flaskamp, Ashretha Ashokkumar, Anne Trefzer, Christine Ried, Veit R Buchholz, Reinhard Obst, Tobias Straub, Thomas Brocker, Jan Kranich (2023 Apr 18) Phosphatidylserine-positive extracellular vesicles boost effector CD8+ T cell responses during viral infection. PNAS 120(16):e2210047120. doi: 10.1073/pnas.2210047120  (Projects B03, B15 and Z02)

Raj T, Negraschus A, Heissmeyer V (2023 Apr 4) Roquin-dependent gene regulation in immune-mediated diseases and future therapies. Int Immunol. 35(4):159-170. doi: 10.1093/intimm/dxac059 (Project A03)

Thomas J. O'Neil, Andreas Gewies, Thomas Seeholzer and Daniel Krappmann (2023 January 24)  TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions. Front. Immunol.,  Sec. T Cell Biology, Volume 14 - 2023. https://doi.org/10.3389/fimmu.2023.1111398 (Project A04)

Matthias Rotheneder, Kristina Stakyte, Erik van de Logt, Joseph D. Bartho, Katja Lammens, Yilan Fan, Aaron Alt, Brigitte Kessler, Christophe Jung, Wynand P. Roos, Barbara Steigenberger, and Karl-Peter Hopfner (2023 Jan 19) Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions, Molecular Cell Volume 83, ISSUE 2, P167-185.e9. https://doi.org/10.1016/j.molcel.2022.12.003 (Project B02)

Ying-Yin Chao, Alisa Puhach, David Frieser, Mahima Arunkumar, Laurens Lehner, Thomas Seeholzer, Albert Garcia-Lopez, Marlot van der Wal, Silvia Fibi-Smetana, Axel Dietschmann, Thomas Sommermann, Tamara Ćiković, Leila Taher, Mark S. Gresnigt, Sebastiaan J. Vastert, Femke van Wijk, Gianni Panagiotou, Daniel Krappmann, Olaf Groß & Christina E. Zielinski (2023 Jan 05) Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation. Nat Immunol. doi: 10.1038/s41590-022-01386-w. Online ahead of print. PMID: 36604548 (Projects A04 and B10)

Ito-Kureha T, Heissmeyer V (2023 Jan) Critical functions of N6-adenosine methylation of mRNAs in T cells. Biochim Biophys Acta Mol Cell Res. 1870(1):119380. doi: 10.1016/j.bbamcr.2022.119380. (Project A03)