Publications
Gesine Behrens, Stephanie L. Edelmann, Timsse Raj, Nina Kronbeck, Thomas Monecke, Elena Davydova, Elaine H. Wong, Lisa Kifinger, Florian Giesert, Martin E. Kirmaier, Christine Hohn, Laura S. de Jonge, Mariano Gonzalez Pisfil, Mingui Fu, Sebastian Theurich, Stefan Feske, Naoto Kawakami, Wolfgang Wurst, Dierk Niessing & Vigo Heissmeyer (23 Nov 2021) Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses. Nat Immunol (2021). https://doi.org/10.1038/s41590-021-01064-3 (Project A03)
Lisa Rausch, Konstantin Lutz, Martina Schifferer, Elena Winheim, Rudi Gruber, Elina F. Oesterhaus, Linus Rinke, Johannes C. Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Christopher Mandel, Michael Bergwelt-Baildon, Mikael Simons, Tobias Straub, Anne B. Krug, Jan Kranich, Thomas Brocker (2021) Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients. Journal of Extracellular Vesicles Vol 10:14, e12173. https://doi.org/10.1002/jev2.12173 (Projects A06 and B03)
Thomas J. O’Neill, Thomas Seeholzer, Andreas Gewies, Torben Gehring, Florian Giesert, Isabel Hamp, Carina Graß, Henrik Schmidt, Katharina Kriegsmann, Marie J. Tofaute, Katrin Demski, Tanja Poth, Marc Rosenbaum, Theresa Schnalzger, Jürgen Ruland, Martin Göttlicher, Mark Kriegsmann, Ronald Naumann, Vigo Heissmeyer, Oliver Plettenburg, Wolfgang Wurst, Daniel Krappmann (12 Nov 2021) TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease. Science Immunology 6 eabh 2095, DOI: 10.1126/sciimmunol.abh2095. (Projects A03, A04, B01)
Winheim, E; Rinke, L; Lutz, K; Reischer, A; Leutbecher, A; Wolfram, L; Rausch, L; Kranich, J; Wratil, PR; Huber, JE; Baumjohann, D; Rothenfusser, S; Schubert, B; Hilgendorff, A; Hellmuth, JC; Scherer, C; Muenchhoff, M; von Bergwelt-Baildon, M; Stark, K; Straub, T; Brocker, T; Keppler, OT; Subklewe, M; Krug, AB (2021) Impaired function and delayed regeneration of dendritic cells in COVID-19. PLoS Pathog, 2021 vol. 17(10) e1009742 (Projects A06, B03 and B12)
Stakyte K, Rotheneder M, Lammens K, Bartho JD, Grädler U, Fuchß T, Pehl U, Alt A, van de Logt E, Hopfner KP (2021) Molecular basis of human ATM kinase inhibition. Nat Struct Mol Biol. 2021 Sep 23. doi: 10.1038/s41594-021-00654-x. PMID: 34556870 (Project B02)
Kai P. Hoefig, Alexander Reim, Christian Gallus, Elaine H. Wong, Gesine Behrens, Christine Conrad, Meng Xu, Lisa Kifinger, Taku Ito-Kureha, Kyra A. Y. Defourny, Arie Geerlof, Josef Mautner, Stefanie M. Hauck, Dirk Baumjohann, Regina Feederle, Matthias Mann, Michael Wierer, Elke Glasmacher & Vigo Heissmeyer (2021) Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation. Nature Communications 12, 5208. https://doi.org/10.1038/s41467-021-25345-5 (Project A03 & B12)
Flommersfeld S, Böttcher JP, Ersching J, Flossdorf M, Meiser P, Pachmayr LO, Leube J, Hensel I, Jarosch S, Zhang Q, Chaudhry MZ, Andrae I, Schiemann M, Busch DH, Cicin-Sain L, Sun JC, Gasteiger G, Victora GD, Höfer T, Buchholz VR*, Grassmann S* (2021) Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection. Immunity. 2021 Aug 20:S1074-7613(21)00332-0. doi: 10.1016/j.immuni.2021.08.002. PMID: 34437840 *joint last authors (Projects B09 and B15)
Kretschmer L, Busch DH, Buchholz VR (2021) A Single-Cell Perspective on Memory T-Cell Differentiation. Cold Spring Harb Perspect Biol. 2021 Sep 1;13(9):a038067. doi: 10.1101/cshperspect.a038067. PMID: 33903160 (Projects B09 and B15)
David S. Fischer, Meshal Ansar, Karolin I. Wagner, Sebastian Jarosch, Yiqi Huang, Christoph H. Mayr, Maximilian Strunz, Niklas J. Lang, Elvira D’Ippolito , Monika Hammel, Laura Mateyka, Simone Weber, Lisa S. Wolff, Klaus Witter, Isis E. Fernandez, Gabriela Leuschner, Katrin Milger, Marion Frankenberger, Lorenz Nowak, Katharina Heinig-Menhard, Ina Koch, Mircea G. Stoleriu, Anne Hilgendorff, Jürgen Behr, Andreas Pichlmair, Benjamin Schubert, Fabian J. Theis, Dirk H. Busch, Herbert B. Schiller, Kilian Schober (2021) Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’. Nat Commun 12, 4515 (2021). https://doi.org/10.1038/s41467-021-24730-4 (Project B09)
Nicholas J. Maurice, Jacqueline Berner, Alexis K. Taber, Dietmar Zehn, Martin Prilic (8 July 2021) Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8+ T cells. JCI Insight. 6 (13): e150744. doi: 10.1172/jci.insight.150744 (Project B14)
Michael Hiltensperger, Eduardo Beltrán, Ravi Kant, Sofia Tyystjärvi, Gildas Lepennetier, Helena Domínguez Moreno, Isabel J. Bauer, Simon Grassmann, Sebastian Jarosch, Kilian Schober, Veit R. Buchholz, Selin Kenet, Christiane Gasperi, Rupert Öllinger, Roland Rad, Andreas Muschaweckh, Christopher Sie, Lilian Aly, Benjamin Knier, Garima Garg, Ali M. Afzali, Lisa Ann Gerdes, Tania Kümpfel, Sören Franzenburg, Naoto Kawakami, Bernhard Hemmer, Dirk H. Busch, Thomas Misgeld, Klaus Dornmair and Thomas Korn (2021) Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity. Nature Immunology (July 2021) 22:880-892. https://doi.org/10.1038/s41590-021-00948-8 (Projects B06, B09 and B15)
Stutte, S., Ruf, J., Kugler, I., Ishikawa-Ankerhold, H., Parzefall, A., Marconi, P., Maeda, T., Kaisho T., Krug, A., Popper, B., Lauterbach, H., Colonna, M., von Andrian, U., Brocker, T. (2021) Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice. Brain, Behavior and Immunity , Vol 95, pp. 429-443. https://doi.org/10.1016/j.bbi.2021.04.018 [Projects A06 & B03]
Friedrich, V., Forné, I., Matzek, D., Ring, D., Popper, B., Jochum, L., Spriewald, S., Straub, T., Imhof, A., Krug, A., Stecher, B., and Brocker, T. (2021). Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice. Gut Microbes. 13, 1-20. https://doi.org/10.1080/19490976.2021.1882928 [Projects A06 & B03]
Trefzer, A., Kadam, P., Wang, S. H., Pennavaria, S., Lober, B., Akcabozan, B., Kranich, J., Brocker, T., Nakano, N., Irmler, M., Beckers, J., Straub, T., Obst, R. (2021) Dynamic adoption of anergy by antigen-exhausted CD4(+) T cells. Cell Rep Vol. 34 Issue 6 Pages 108748. Accession Number: 33567282, DOI: 10.1016/j.celrep.2021.108748. (Projects B03 and B07)
