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Publications 2014

Andreas Gewies, Oliver Gorka, Hanna Bergmann, Konstanze Pechloff, Franziska Petermann, Katharina M. Jeltsch, Martina Rudelius, Mark Kriegsmann, Wilko Weichert, Marion Horsch,, Johannes Beckers, Wolfgang Wurst, Mathias Heikenwalder, Thomas Korn, Vigo Heissmeyer, Jürgen Ruland. (2014) Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation. Cell, Volume 9, Issue 4, 20 November 2014, 1292-1305. [Project A03, B01, B06]

Krappmann D, Nagel D, Schlauderer F, Lammens K, Hopfner KP, Chrusciel RA, Kling DL. The (S)-enantiomer of Mepazine. Published 31.12.2014, WO/2014/207067 [Project A04, B02]

J. Christoph Vahl, Christoph Drees, Klaus Heger, Sylvia Heink, Julius C. Fischer, Jelena Nedjic, Naganari Ohkura, Hiromasa Morikawa, Hendrik Poeck, Sonja Schallenberg, David Rieß, Marco Y. Hein, Thorsten Buch, Bojan Polic, Anne Schönle, Robert Zeiser, Annette Schmitt-Gräff, Karsten Kretschmer, Ludger Klein, Thomas Korn, Shimon Sakaguchi, Marc Schmidt-Supprian. (2014) Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell PoolHighlights. Immunity. Volume 41, Issue 5, p722-736, 2014. [Project A01, A02, B06]

Zielinski, C.E. (2014) Microbe driven T-helper cell differentiation: lessons from Candida albicans and Staphylococcus aureus. Exp Dermatol 23: 795-798. [Project B10]

Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V. (2014) Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Nat Immunol. 2014 Nov, 15(11): 1079-89. [Project A02, A03, A04, B01]

Stefanie Eyerich, Christina E. Zielinski. (2014) Defining Th-cell subsets in a classical and tissue-specific manner: Examples from the skin.
Eur. J. Immunol. 2014. 44: 3475-3483. [Project B10]

Yvonne Döring, Maik Drechsler, Oliver Soehnlein, Christian Weber. (2014) Neutrophils in Atherosclerosis: From Mice to Man. Arterioscler Thromb Vasc Biol. 2014; 35. [Project B04]

Zielinski C.E. (2014) Autoimmunity beyond Th17: GM-CSF producing T cells. Cell Cycle 13: 2489-2490. [Project B10]

Schlundt A, Heinz GA, Janowski R, Geerlof A, Stehle R, Heissmeyer V, Niessing D, Sattler M. (2014) Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation. Nat Struct Mol Biol. 2014 Aug, 21(8): 671-8. [Project A03]

Mc Guire C, Elton L, Wieghofer P, Staal J, Voet S, Demeyer A, Nagel D, Krappmann D, Prinz M, Beyaert R, van Loo G . (2014) Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis. J Neuroinflammation 2014; 11: 124. [Project A04]

Graef P, Buchholz VR, Stemberger C, Flossdorf M, Henkel L, Schiemann M, Drexler I, Höfer T, Riddell SR, Busch DH. (2014) Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells. Immunity 41, 116-126, July 17, 2014. [Project B09]

Goettel, J.A., Biswas, S., Lexmond, W.S., Yeste, A., Passerini L., Patel B., Yang S., Sun J., Ouahed J., Shouval D.S., McCann K.J., Horwitz B.H., Mathis D., Milford E.L., Notarangelo L.D., Roncarolo M-G., Fiebiger E., Marasco W.A., Bacchetta R., Quintana F.J., Pai S-Y., Klein C., Muise A.M., Snapper S.B.. (2014). Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood 125, 3886-3895 [Project A05]

Tom Seijkens, Marten A. Hoeksema, Linda Beckers, Esther Smeets, Svenja Meiler, Johannes Levels, Marc Tjwa, Menno P.J. de Winther, Esther Lutgens. (2014) Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis. FASEB J. 28, Vol. 28. (2014). [Project B08]

Noster, R., R. Riedel, M. F. Mashreghi, H. Radbruch, L. Harms, C. Haftmann, H. D. Chang, A. Radbruch, and C. E. Zielinski. (2014) IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Sci Transl Med 6: 241ra280. [Project B10]

Roth, S., Rottach, A., Lotz-Havla, A.S., Laux, V., Muschaweckh, A., Gersting, S.W., Muntau, A.C., Hopfner, K.P., Jin, L., Vanness, K., Petrini, J.H., Drexler, I., Leonhardt, H. and Ruland, J. (2014) Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1beta production. Nat Immunol 15, 538-545. [Project B01, B02]

Ludger Klein, Bruno Kyewski, Paul M. Allen, Kristin A. Hogquist. (2014) Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nature Reviews Immunology 14, 377-391 (2014). [Project A01]

Antonios Chatzigeorgiou, Kyoung-Jin Chung, Ruben Garcia-Martin, Vasileia-Ismini Alexaki, Anne Klotsche-von Ameln, Julia Phieler, David Sprott, Waldemar Kanczkowski, Theodora Tzanavari, Mohktar Bdeir, Sibylle Bergmann, Marc Cartellieri, Michael Bachmann, Ployxeni Nikolakopoulou, Andreas Androutsellis-Theotokis, Gabriele Siegert, Stefan R. Bornstein, Michael H. Muders, Louis Boon, Katia P. Karalis, Esther Lutgens, Triantafyllos Chavakis. (2014) Dual Role of B7 Costimulation in Obesity-Related Non-alcoholic Steatohepatitis and Metabolic Dysregulation. Hepatology 2014; 60:1196-1210. [Project B08]

Rabenstein, H., Behrendt, A.C., Ellwart, J.W., Naumann, R., Horsch, M., Beckers, J., and Obst, R. (2014). Differential kinetics of antigen dependency of CD4+ and CD8+ T cells. J Immunol 192, 3507-3517 [Project B07]

Neumann K, Castiñeiras-Vilariño M, Höckendorf U, Hannesschläger N, Lemeer S, Kupka D, Meyermann S, Lech M, Anders HJ, Kuster B, Busch DH, Gewies A, Naumann R, Groß O, Ruland J. (2014) Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Immunity 40, 389-399, March 20, 2014. [Project B01, B09]

Christina Heinemann, Sylvia Heink, Franziska Petermann, Ajithkumar Vasanthakumar, Veit Rothhammer, Elien Doorduijn, Meike Mitsdoerffer, Christopher Sie, Olivia Prazeres da Costa, Thorsten Buch, Bernhard Hemmer, Mohamed Oukka, Axel Kallies & Thomas Korn. (2014) IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1. Nature Communications, 5:3770. [Project B06]

Dhaarini Murugan, Michael H. Albert, Jörg Langemeier, Jens Bohne, Jacek Puchalka, Päivi M. Järvinen, Fabian Hauck, Anne K. Klenk, Christine Prell, Stephanie Schatz, Jana Diestelhorst, Barbara Sciskala, Naschla Kohistani, Bernd H. Belohradsky, Susanna Müller, Thomas Kirchner, Mark R. Walter, Philip Bufler, Aleixo M. Muise, Scott B. Snapper, Sibylle Koletzko, Christoph Klein, Daniel Kotlarz. (2014) Very Early Onset Inflammatory Bowel Disease Associated with Aberrant Trafficking of IL-10R1 and Cure by T Cell Replete Haploidentical Bone Marrow Transplantation. J Clin Immunol (2014) 34:331-339. [Project A05]

David T. Vereide, Eri Seto, Ya-Fang Chiu, Mitchell Hayes, Takanobu Tagawa, Adam Grundhoff, Wolfgang Hammerschmidt, Bill Sugden. (2015) Epstein-Barr virus maintains lymphomas via its miRNAs. Oncogene 2014 Mar 6; 33(10): 1258-1264. [Project B05]

Antonios Chatzigeorgiou, Tom Seijkens, Barbara Zarzycka, David Engel, Marjorie Poggi, Susan van den Berg, Sjoerd van den Berg, Oliver Soehnlein, Holger Winkels, Linda Beckers, Dirk Lievens, Ann Drissen, Pascal Kusters, Erik Biessen, Ruben Garcia-Martin, Anne Klotzsche-von Ameln, Marion Gijbels, Randolph Noelle, Louis Boon, Tilman Hackeng, Klaus-Martin Schulte, Aimin Xu, Gert Vriend, Sander Nabuurs, Kyoung-Jin Chung, Ko Willems van Dijk, Patrick C.N. Rensen, Norbert Gerdes, Menno de Winther, Norman L. Block, Andrew V. Schally, Christian Weber, Stefan R. Bornstein, Gerry Nicolaes, Triantafyllos Chavakis, Esther Lutgens. (2014) Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci USA. 2014 Feb 18; 111(7); 2686-2691. [Project B04, B08]

Veit Rothhammer, Andreas Muschaweckh, Georg Gasteiger, Franziska Petermann, Sylvia Heink, Dirk H Busch, Mathias Heikenwälder, Bernhard Hemmer, Ingo Drexler, and Thomas Korn. (2014) α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets. Acta Neuropathol Commun. 2014; 2:27. [Project B06, B09]


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