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Publications 2018

Knier, B., Hiltensperger, M., Sie, C., Aly, L., Lepennetier, G., Engleitner, T., Garg, G., Muschaweckh, A., Mitsdörffer, M., Koedel, U., Höchst, B., Knolle, P., Gunzer, M., Hemmer, B., Rad, R., Merkler, D., and Korn, T. (2018). Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity. Nat. Immunol. 19, 1341–1351. doi: 10.1038/s41590-018-0237-5. [Project B06]

Seeholzer, T., Kurz, S., Schlauderer, F., Woods, S., Gehring, T., Widmann, S., Lammens, K., and Krappmann, D. (2018). BCL10-CARD11 fusion mimics an active CARD11 seed that triggers constitutive BCL10 oligomerization and lymphocyte activation. Front. Immunol. 9, 1–16. doi: 10.3389/fimmu.2018.02695. [Projects A04 and B02]

Bardet, M., Seeholzer, T., Unterreiner, A., Woods, S., Krappmann, D., and Bornancin, F. (2018). MALT1 activation by TRAF6 needs neither BCL10 nor CARD11. Biochem. Biophys. Res. Commun. 506, 48–52. doi: 10.1016/j.bbrc.2018.10.029. [Project A04]

Kasper, L., König, A., Koenig, P.A., Gresnigt, M.S., Westman, J., Drummond, R.A., Lionakis, M.S., Groß, O., Ruland, J., Naglik, J.R., and Hube, B. (2018). The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat. Commun. 9. doi: 10.1038/s41467-018-06607-1. [Project B01]

Schlauderer, F., Seeholzer, T., Desfosses, A., Gehring, T., Strauss, M., Hopfner, K.P., Gutsche, I., Krappmann, D., and Lammens, K. (2018). Molecular architecture and regulation of BCL10-MALT1 filaments. Nat. Commun. 9. doi: 10.1038/s41467-018-06573-8. [Projects A04 and B02]

Essig, K., Kronbeck, N., Guimaraes, J.C., Lohs, C., Schlundt, A., Hoffmann, A., Behrens, G., Brenner, S., Kowalska, J., Lopez-Rodriguez, C., Jemielity, J., Holtmann, H., Reiche,K., Hackermüller, J., Sattler, M., Zavolan, M., and Heissmeyer, V. (2018). Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation. Nat. Commun. 9. doi: 10.1038/s41467-018-06184-3. [Project A03]

Zimmermann, H.G., Knier, B., Oberwahrenbrock, T., Behrens, J., Pfuhl, C., Aly, L., Kaminski, M., Hoshi, M.M., Specovius, S., Giess, R.M., Scheel, M., Mühlau, M., Bellmann-Strobl, J., Ruprecht, K., Hemmer, B., Korn, T., Paul, F., and Brandt, A.U. (2018). Association of retinal ganglion cell layer thickness with future disease activity in patients with clinically isolated syndrome. JAMA Neurol. 75, 1071–1079. doi: 10.1001/jamaneurol.2018.1011. [Project B06]

Brenke, J.K., Popowicz, G.M., Schorpp, K., Rothenaigner, I., Roesner, M., Meininger, I., Kalinski, C., Ringelstetter, L., R’kyek, O., Vincendeau, M., Plettenburg, O., Krappmann, D., and Hadian K. (2018). Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity. J. Biol. Chem. 293, 13191–13203. doi: 10.1074/jbc.RA118.002649. [Project A04]

Hoefig, K.P., and Heissmeyer, V. (2018). Posttranscriptional regulation of T helper cell fate decisions. J. Cell Biol. 217, 2615–2631. doi: 10.1083/jcb.201708075. [Project A03]

Somekh, I., Marquardt, B., Liu, Y., Rohlfs, M., Hollizeck, S., Karakukcu, M., Unal, E., Yilmaz, E., Patiroglu, T., Cansever, M., Frizinsky, S., Vishnvenska-Dai, V., Rechavi, E., Stauber, T., Simon, A.J., Lev, A., Klein, C., Kotlarz, D., and Somech, R. (2018). Novel Mutations in RASGRP1 are Associated with Immunodeficiency, Immune Dysregulation, and EBV-Induced Lymphoma. J. Clin. Immunol. 38, 699–710. doi: 10.1007/s10875-018-0533-8. Epub 2018 Jul 20. [Project A05]

Baumjohann, D., and Heissmeyer, V. (2018). Posttranscriptional Gene Regulation of T Follicular Helper Cells by RNA-Binding Proteins and microRNAs. Front. Immunol. 9, 1794. doi: 10.3389/fimmu.2018.01794. [Project A03 and B12]

Lässig, C., Lammens, K., López, J.L.G., Michalski, S., Fettscher, O., and Hopfner, K.P. (2018). Unified mechanisms for self-RNA recognition by RIG-I singleton-merten syndrome variants. Elife 7, 1–17. doi: 10.7554/eLife.38958. [Project B02]

Serr, I., and Daniel, C. (2018). Regulation of T follicular helper cells in islet autoimmunity. Front. Immunol. 9. doi: 10.3389/fimmu.2018.01729. [Project B11]

Gehring, T., Seeholzer, T., and Krappmann, D. (2018). BCL10-Bridging CARDs to immune activation. Front. Immunol. 9, 1–10. doi: 10.3389/fimmu.2018.01539. [Project A04]

Garbers, C., Heink, S., Korn, T., and Rose-John, S. (2018). Interleukin-6: Designing specific therapeutics for a complex cytokine. Nat. Rev. Drug Discov. 17, 395–412. doi: 10.1038/nrd.2018.45. [Project B06]

Baumjohann, D. (2018). Diverse functions of miR-17–92 cluster microRNAs in T helper cells. Cancer Lett. 423, 147–152. doi: 10.1016/j.canlet.2018.02.035. doi: 10.3389/fimmu.2018.01794 [Project B12]

Behrens, G., Winzen, R., Rehage, N., Anneke, D., Barsch, M., Hoffmann, A., Tiedje, C., Heissmeyer, V., and Holtmann, H. (2018). A translational silencing function of MCPIP1/Regnase-1 specified by the target site context. Nucleic Acids Res. 46, 4256–4270. doi: 10.1093/nar/gky106. [Project A03]

Schober, K., Buchholz, V.R., and Busch, D.H. (2018). TCR repertoire evolution during maintenance of CMV-specific T-cell populations. Immunol. Rev. 283, 113–128. doi: 10.1111/imr.12654. [Project B09]

Markey, K.A., Kuns, R.D., Browne, D.J., Gartlan, K.H., Robb, R.J., Paulo Martins, J., Henden, A.S., Minnie, S.A., Cheong, M., Koyama, M., Smyth, M.J., Steptoe, R.J., Belz, G.T., Brocker, T., Degli-Esposti, M.A., Lane, S.W., and Hill, G.R. (2018). Flt-3L expansion of recipient CD8aþ dendritic cells deletes alloreactive donor T cells and represents an alternative to posttransplant cyclophosphamide for the prevention of GVHD. Clin. Cancer Res. 24, 1604–1616. doi: 10.1158/1078-0432.CCR-17-2148. [Project B03]

Patzelt, T., Keppler, S.J., Gorka, O., Thoene, S., Wartewig, T., Reth, M., Förster, I., Lang, R., Buchner, M., and Ruland, J. (2018). Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells. Proc. Natl. Acad. Sci. U. S. A. 115, 3120–3125. doi: 10.1073/pnas.1711335115. [Project B01]

Kotlarz, D., Marquardt, B., Barøy, T., Lee, W.S., Konnikova, L., Hollizeck, S., Magg, T., Lehle, A.S., Walz, C., Borggraefe, I., Hauck, F., Bufler, P., Conca, R., Wall, S.M., Schumacher, E.M., Misceo, D. Frengen, E., Bentsen, B.S., Uhlig, H.H., Hopfner, K.-P., Muise, A.M., Snapper, S.B., Strømme, P., and Klein, C. (2018). Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy. Nat. Genet. 50, 344–348. doi: 10.1038/s41588-018-0063-6. [Project A05]

Rehage, N., Davydova, E., Conrad, C., Behrens, G., Maiser, A., Stehklein, J.E., Brenner, S., Klein, J., Jeridi, A., Hoffmann, A., Lee, E., Dianzani, U., Willemsen, R., Feederle, R., Reiche, K., Hackermüller, J., Leonhardt, H., Sharma, S., Niessing, D., and Heissmeyer, V. (2018). Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Nat. Commun. 9. doi: 10.1038/s41467-017-02582-1. [Project A03]

Shinde, P. V., Xu, H.C., Kumar Maney, S., Kloetgen, A., Namineni, S., Zhuang, Y., Honke, N., Shaabani, N., Bellora, N., Doerrenber, M., Trillig, M., Pozdeev, V.I., van Rooijen, N., Scheu, S., Pfeffer, K., Crocker, P.R., Tanaka, M., Duggimpudi, S., Knolle, P., Heikenwalder, M., Ruland, J., Mak, T.W., Brenner, D., Pandyra, A.A., Hoell, J.I., Borkhardt, A., Häussinger, D. Lang, K.S., and Lang, P.A. (2018). Tumor Necrosis Factor-Mediated Survival of CD169+Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection. J. Virol. 92, 1–18. doi: 10.1128/JVI.01637-17. [Project B01]

Serr, I., Scherm, M.G., Zahm, A.M., Schug, J., Victoria, K., Hippich, M., Kälin, S., Becker, M., Achenbach, P., Gerlach, K., Liebsch, N., Loretz, B., Lehr, C.-M., Kirchner, B., Spornraft, M., Haase, B., Segars, J., Küper, C., Palmisano, R., Waisman, A., Willis, R.A., Kim, W.-U., Weigmann, B., Kaestner, K.H., Ziegler, A.-G., and Daniel, C. (2018). A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes. Sci. Transl. Med. 10. doi: 10.1126/scitranslmed.aag1782. [Project B11]

Hiltensperger, M., and Korn, T. (2018). The interleukin (IL)-23/T helper (Th)17 axis in experimental autoimmune encephalomyelitis and multiple sclerosis. Cold Spring Harb. Perspect. Med. 8, 1–17. doi: 10.1101/cshperspect.a029637. [Project B06]

Gelderblom, M., Gallizioli, M., Ludewig, P., Thom, V., Arunachalam, P., Rissiek, B., Bernreuther, C., Glatzel, M., Korn, T., Arumugam, T.V., Sedlacik, J., Gerloff, C., Tolosa, E., Planas, A.M., and Magnus, T. (2018). IL-23 (Interleukin-23)–Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke. Stroke 49, 155–164. doi: 10.1161/STROKEAHA.117.019101. [Project B06]


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