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Publications 2017

Schneider, K.S., Groß, C.J., Dreier, R.F., Saller, B.S., Mishra, R., Gorka, O., Heilig, R., Meunier, E., Dick, M.S., Ćiković, T., Sodenkamp, J., Guillaume, M., Naumann, R., Ruland, J., Kuster, B., Broz, P., and Groß, O. (2017). The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. Cell Rep. 21, 3846–3859. doi: 10.1016/j.celrep.2017.12.018. [Project B01]

Essig, K., Hu, D., Guimaraes, J.C., Alterauge, D., Edelmann, S., Raj, T., Kranich, J., Behrens, G., Heiseke, A., Floess, S., Klein, J., Maiser, A., Marschall, A., Marschall, S., Hrabĕ de Angelis,M., Leonhardt, H., Calkhoven, C.F., Noessner, E., Brocker, T., Huehn, J., Krug, A., Zavolan M, Baumjohann, D. , and Heissmeyer, V. (2017). Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity 47, 1067-1082.e12. doi: 10.1016/j.immuni.2017.11.008. [Projects A03, A06, B03 and B12]

Wartewig, T., Kurgyis, Z., Keppler, S., Pechloff, K., Hameister, E., Öllinger, R., Maresch, R., Buch, T., Steiger, K., Winter, C., Rad, R., and Ruland, J. (2017). PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis. Nature 552, 121–125. doi: 10.1038/nature24649. [Project B01]

Kusters, P., Seijkens, T., Bürger, C., Legein, B., Winkels, H., Gijbels, M., Barthels, C., Bennett, R., Beckers, L., Atzler, D., Biessen, E., Brocker, T., Weber, C., Gerdes, N. and Lutgens, E. (2017). Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption. Am. J. Pathol. 187, 2912–2919. doi: 10.1016/j.ajpath.2017.08.016. [Project B03]

Shouval, D.S., Konnikova, L., Griffith, A.E., Wall, S.M., Biswas, A., Werner, L., Nunberg, M., Kammermeier, J., Goettel, J.A., Anand, R., Chen, H., Weiss, B., Li, J., Loizides, A., Yerushalmi, B., Yanagi, T., Beier, R., Conklin, L.S., Ebens, C.L., Santos, F.G.M.S., Sherlock, M., Goldsmith, J.D., Kotlarz, D., Glover, S., Shah, N., Bousvaros, A., Uhlig, H.H., Muise, A.M., Klein, C., and Snapper, S.. (2017). Enhanced TH 17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD. Inflamm. Bowel Dis. 23, 1950–1961. doi: 10.1097/MIB.0000000000001270. [Project A05]

Wang, L., Winnewisser, J., Federle, C., Jessberger, G., Nave, K.A., Werner, H.B., Kyewski, B., Klein, L., and Hinterberger, M. (2017). Epitope-specific tolerance modes differentially specify susceptibility to proteolipid protein-induced experimental autoimmune encephalomyelitis. Front. Immunol. 8. doi: 10.3389/fimmu.2017.01511. [Project A01]

Becker, M., Levings, M.K., and Daniel, C. (2017). Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk. Eur. J. Immunol. 47, 1867–1874. doi: 10.1002/eji.201646739. [Project B11]

Prajeeth, C.K., Kronisch, J., Khorooshi, R., Knier, B., Toft-Hansen, H., Gudi, V., Floess, S., Huehn, J., Owens, T., Korn, T., and Stangel, M. (2017). Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties. J. Neuroinflammation 14, 1–14. doi: 10.1186/s12974-017-0978-3. [Project B06]

Muschaweckh, A., Petermann, F., and Korn, T. (2017). IL-1β and IL-23 Promote Extrathymic Commitment of CD27+CD122− γδ T Cells to γδT17 Cells. J. Immunol. 199, 2668–2679. doi: 10.4049/jimmunol.1700287. [Project B06]

Bahrami, E., Witzel, M., Racek, T., Puchałka, J., Hollizeck, S., Greif-Kohistani, N., Kotlarz, D., Horny, H.P., Feederle, R., Schmidt, H., Sherkat, R., Steinemann, D., Göhring, G., Schlegelberger, B., Albert, M.H., Al-Herz, Q., and Klein, C. (2017). Myb-like, SWIRM, and MPN domains 1 (MYSM1) deficiency: Genotoxic stress-associated bone marrow failure and developmental aberrations. J. Allergy Clin. Immunol. 140, 1112–1119. doi: 10.1016/j.jaci.2016.10.053. [Project A05]

Zielinski, C.E. (2017). Human T cell immune surveillance: Phenotypic, functional and migratory heterogeneity for tailored immune responses. Immunol. Lett. 190, 125–129. doi: 10.1016/j.imlet.2017.08.001. [Project B10]

Fischer, J.C., Otten, V., Kober, M., Drees, C., Rosenbaum, M., Schmickl, M., Heidegger, S., Beyaert, R., van Loo, G., Li, X.C., Peschel, C., Schmidt-Supprian, M., Haas, T., Spoerl, S. and Poeck, H. (2017b). A20 Restrains Thymic Regulatory T Cell Development. J. Immunol. 199, 2356–2365. doi: 10.4049/jimmunol.1602102. [Project A02]

Kälin, S., Becker, M., Ott, V.B., Serr, I., Hosp, F., Mollah, M.M.H., Keipert, S., Lamp, D., Rohner-Jeanrenaud, F., Flynn, V.K., Scherm, M.G., Nascimento, L.F.R., GErlach, K, Popp, V., Dietzen, S., Bopp, T., Krishnamurthy, P., Kaplan, M.H., Serrano, M., Woods, S.C., Tripal, P., Palmisano, R., Jastroch, M., Blüher, M., Wolfrum, C., Weigmann, B., Ziegler, A.-G., Mann, M., Tschöp, M.H., and Daniel, C. (2017). A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metab. 26, 475–492. doi: 10.1016/j.cmet.2017.08.008. [Project B11]

Bergmann, H., Roth, S., Pechloff, K., Kiss, E.A., Kuhn, S., Heikenwälder, M., Diefenbach, A., Greten, F.R., and Ruland, J. (2017). Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer. Eur. J. Immunol. 47, 1342–1353. doi: 10.1002/eji.201646765. [Project B01]

Cho, Y.L., Flossdorf, M., Kretschmer, L., Höfer, T., Busch, D.H., and Buchholz, V.R. (2017). TCR Signal Quality Modulates Fate Decisions of Single CD4+ T Cells in a Probabilistic Manner. Cell Rep. 20, 806–818. doi: 10.1016/j.celrep.2017.07.005. [Project B09]

Montoya, M.M., Maul, J., Singh, P.B., Pua, H.H., Dahlström, F., Wu, N., Huang, X., Ansei, K.M., and Baumjohann, D. (2017). A distinct inhibitory function for miR-18a in Th17 cell differentiation. J. Immunol. 199, 559–569. doi: 10.4049/jimmunol.1700170. [Project B12]

Knier, B., Leppenetier, G., Wetzlmair, C., Aly, L., Hoshi, M.M., Pernpeintner, V., Biberacher, V., Berthele, A., Mühlau, M., Zimmer, C., Hemmer, B., and Korn, T. (2017). Association of retinal architecture, intrathecal immunity, and clinical course in multiple sclerosis. JAMA Neurol. 74, 847–856. doi: 10.1001/jamaneurol.2017.0377. [Project B06]

Haas, T., Heidegger, S., Wintges, A., Bscheider, M., Bek, S., Fischer, J.C., Eisenkolb, G., Schmickl, M., Spoerl, S., Peschel, C., poeck, H., and Ruland, J. (2017). Card9 controls Dectin-1-induced T-cell cytotoxicity and tumor growth in mice. Eur. J. Immunol. 47, 872–879. doi: 10.1002/eji.201646775. [Project B01]

Fischer, J.C., Bscheider, M., Eisenkolb, G., Lin, C.C., Wintges, A., Otten, V., Lindemans, C.A., Heidegger, S., Rudelius, M., Monette, S., Porosnicu Rodriguez, K.A., Calafiore, M., Liebermann, S., Liu, C., Lienenklaus, S., Weiss, S., Kalinke, U., Ruland, J., Peschel, C., Shono, Y., Docampo, M., Velardi, E., Jenq, R.R., van den Brink, M.R.M., and Poeck, H. (2017a). RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. Sci. Transl. Med. 9, 1–14. doi: 10.1126/scitranslmed.aag2513. [Project B01]

Schuh, E., Musumeci, A., Thaler, F.S., Laurent, S., Ellwart, J.W., Hohlfeld, R., Krug, A., and Meinl, E. (2017). Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement. J. Immunol. 198, 3081–3088. doi: 10.4049/jimmunol.1601746. [Project A06]

Drees, C., Vahl, J.C., Bortoluzzi, S., Heger, K.D., Fischer, J.C., Wunderlich, F.T., Peschel, C., and Schmidt-Supprian, M. (2017). Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets. J. Immunol. 198, 2747–2759. doi: 10.4049/jimmunol.1601732. [Project A02]

Korn, T., and Kallies, A. (2017). T cell responses in the central nervous system. Nat. Rev. Immunol. 17, 179–194. doi: 10.1038/nri.2016.144. [Project B06]

Barthels, C., Ogrinc, A., Steyer, V., Meier, S., Simon, F., Wimmer, M., Blutke, A., Straub, T., Zimber-Strobl, U., Lutgens, E., Marconi, P, Ohnmacht C., Garzetti, D., Stecher, B., and Brocker, T. (2017). CD40-signalling abrogates induction of ROR3t + Treg cells by intestinal CD103 + DCs and causes fatal colitis. Nat. Commun. 8. doi: 10.1038/ncomms14715. [Project B03]

Vogel, A.L., Knier, B., Lammens, K., Kalluri, S.R., Kuhlmann, T., Bennett, J.L., and Korn, T. (2017). Deletional tolerance prevents AQP4-directed autoimmunity in mice. Eur. J. Immunol. 47, 458–469. doi: 10.1002/eji.201646855. [Projects B02 and B06]

Sie, C., and Korn, T. (2017). Dendritic cells in central nervous system autoimmunity. Semin. Immunopathol. 39, 99–111. doi: 10.1007/s00281-016-0608-7. [Project B06]

Schimmack, G., Schorpp, K., Kutzner, K., Gehring, T., Brenke, J.K., Hadian, K., and Krappmann, D. (2017). YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB. Elife 6, 1–24. doi: 10.7554/eLife.22416. [Project A04]

Heink, S., Yogev, N., Garbers, C., Herwerth, M., Aly, L., Gasperi, C., Husterer, V., Croxford, A.L., Möller-Hackbarth, K., Bartsch, H.S., Sotlar, K., Krebs, S., Regen, T., Blum, H., Hemmer, B., Misgeld, T., Wunderlich, T.F., Hidalgo, J., Oukka, M., Rose-John, S., Schmidt-Supprian, M., Waisman, A., and Korn, T. (2017). Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat. Immunol. 18, 74–85. doi: 10.1038/ni.3632. [Projects A02 and B06]

 


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