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Publications

Chlis, N.-K., Rausch, L., Brocker, T., Kranich, J., and Theis, F.J. (2020). Predicting single-cell gene expression profiles of imaging flow cytometry data with machine learning. Nucleic Acids Res. 7, 690–12. http://doi.org/10.1093/nar/gkaa926

Michalski, S., de Oliveira Mann, C.C., Stafford, C., Witte, G., Bartho, J., Lammens, K., Hornung, V., and Hopfner, K.P. (2020). Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature 587, 678-682. 10.1038/s41586-020-2748-0 [Project B02]

Chlis, N.-K., Rausch, L., Brocker, T., Kranich, J., and Theis, F.J. (2020). Predicting single-cell gene expression profiles of imaging flow cytometry data with machine learning. Nucleic Acids Res. 7, 690–12. http://doi.org/10.1093/nar/gkaa926 [Project B03]
Grassmann, S., Mihatsch, L., Mir, J., Kazeroonian, A., Rahimi, R., Flommersfeld, S., Schober, K., Hensel, I., Leube, J., Pachmayr, L.O., Kretschmer L., Zhang Q., Jolly A., Chaudhry M.Z., Schiemann M., Cicin-Sain L., Höfer T., Busch D.H., Flossdorf M., Buchholz V.R. (2020). Early emergence of T central memory precursors programs clonal dominance during chronic viral infection. Nat. Immunol. 21, 1563-1573doi: 10.1038/s41590-020-00807-y [Project B09]

Schober, K., Voit, F., Grassmann, S., Müller, T.R., Eggert, J., Jarosch, S., Weißbrich, B., Hoffmann, P., Borkner, L., Nio, E., Fanchi L., Clouser C.R., Radhakrishnan A., Mihatsch L., Lückemeier P., Leube J., Dössinger G., Klein L., Neuenhahn M., Oduro J.D., Cicin-Sain L., Buchholz V.R., Busch D.H.(2020). Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection. Nat. Immunol. 21, 434–441. doi: 10.1038/s41590-020-0628-2. [Project A01 and B09]

Kutukculer, N.*, Seeholzer, T.*, O’Neill, T.J., Graß, C., Aykut, A., Karaca, N.E., Durmaz, A., Cogulu, O., Aksu, G., Gehring, G., Gewies, A., Krappmann D. (2020). Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant. D. J Allergy Clin Immunol. S0091-6749(20)31171-4. doi: 10.1016/j.jaci.2020.07.034 *equal contribution [Project  A04]

Kranich, J., Chlis, N.-K., Rausch, L., Latha, A., Schifferer, M., Kurz, T., Kia, A.F.-A., Simons, M., Theis, F.J., and Brocker, T. (2020). In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning. J. Extracell. Vesicles 9, http://doi.org/10.1080/20013078.2020.1792683 [Project B03]

Huber, J.E., Ahlfeld, J., Scheck, M.K., Zaucha, M., Witter, K., Lehmann, L., Karimzadeh, H., Pritsch, M., Hoelscher, M., von Sonnenburg, F., Dick, A., Barba‐Spaeth, G., Krug, A.B., Rothenfußer, S. and Baumjohann, D. (2020). Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination. Clin Transl Immunol, 9: e1129. doi:10.1002/cti2.1129 [Projects A06 and B12]

Matthias, J., Heink, S., Picard, F., Zeiträg, J., Kolz, A., Chao, Y.Y., Soll, D., Almeida, G., Glasmacher, E., Jacobsen, I.D., Riedel, T., Peters, A., Baumjohann, D., Huber, M., Korn, T., and Zielinski, C. (2020). Salt generates anti-inflammatory Th17 cells but amplifies pathogenicity in pro-inflammatory cytokine microenvironments. J. Clin. Invest. (2020). 130 (9):4587-4600. doi: 10.1172/JCI137786. [Project B06, B10, B12]

Zeiträg, J., Alterauge, D., Dahlström, F., and Baumjohann, D. (2020). Gene Dose Matters: Considerations for the Use of Inducible CD4-CreERT2 Mouse Lines. Eur. J. Immunol. 50, 603-605 doi: 10.1002/eji.201948461. [Project B12]

Schmidt, A., Huber, J.E., Alp, S., Robert, G., Reichel, C.A., Herrmann, M., Keppler, O.T., Leeuw, T., and Baumjohann, D. (2020). Complex human adenoid tissue-based ex vivo culture systems reveal anti- in fl ammatory drug effects on germinal center T and B cells. EbioMedicine. 53, 1–16. doi: 10.1016/j.ebiom.2020.102684. [Project B12]

Huber, J.E., Chang, Y., Meinl, I., Kümpfel, T., Meinl, E., and Baumjohann, D. (2020). Fingolimod Profoundly Reduces Frequencies and Alters Subset Composition of Circulating T Follicular Helper Cells in Multiple Sclerosis Patients. J. Immunol. 204, 1101-1110 doi: 10.4049/jimmunol.1900955 [Project B12]

Jardine, S., Anderson, S., Babcock, S., Leung, G., Pan, J., Dhingani, N., Warner, N., Guo, C., Siddiqui, I., Kotlarz, D., Dowling, J.J., Melnyk, R., Snapper, S.B., Klein, C., Thiagarajah, J.R., and Muise, A.M. (2020). Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency. Gastroenterology 158, 1000–1015. doi: 10.1053/j.gastro.2019.11.019 [Project A05]

Mufazalov, I.A., Andruszewski, D., Schelmbauer, C., Heink, S., Blanfeld, M., Masri, J., Tang, Y., Schüler, R., Eich, C., Wunderlich, F.T., Karbach, S.H., Bluestone, J.A., Korn, T., and Waisman, A. (2020). Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression. J. Immunol. 204, 747–751. doi: 10.4049/jimmunol.1900876. [Project B06]

Kretschmer, L., Flossdorf, M., Mir, J., Cho, Y.L., Plambeck, M., Treise, I., Toska, A., Heinzel, S., Schiemann, M., Busch, D.H., and Buchholz, V.R. (2020). Differential expansion of T central memory precursor and effector subsets is regulated by division speed. Nat. Commun. 11. doi: 10.1038/s41467-019-13788-w. [Project B09]

Jansma, M., Linke-Winnebeck, C., Eustermann, S., Lammens, K., Kostrewa, D., Stakyte, K., Litz, C., Kessler, B., and Hopfner, K.P. (2020). Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure 28, 83-95.e5. doi: 10.1016/j.str.2019.10.013. [Project B02]

 


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