Publications

Zhana Haimon, Gal Ronit Frumer, Jung-Seok Kim, Sébastien Trzebanski, Rebecca Haffner-Krausz, Shifra Ben-Dor, Ziv Porat, Andreas Muschaweckh, Louise Chappell-Maor, Sigalit Boura-Halfon, Thomas Korn & Steffen Jung (2022 Dec 01) Cognate microglia–T cell interactions shape the functional regulatory T cell pool in  experimental autoimmune encephalomyelitis pathology. Nature Immunology. https://doi.org/10.1038/s41590-022-01360-6 (Project B06)

Elena Winheim, Tabea Eser, Flora Deák, Mohamed I. M. Ahmed, Olga Baranov, Linus Rinke, Katharina Eisenächer, Antonio Santos-Peral, Hadi Karimzadeh, Michael Pritsch, Clemens Scherer, Maximilian Muenchhoff, Johannes C. Hellmuth, Michael von Bergwelt-Baildon, Laura Olbrich, Michael Hoelscher, Andreas Wieser, Inge Kroidl, Simon Rothenfusser, Christof Geldmacher, Anne B. Krug (2022 Nov 20) Distinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID-19 and after yellow fever vaccination. Eur J Immunology. doi: 10.1002/eji.202250090. PMID: 36404054 (Project A06)

Madlaina von Hoesslin, Miriam Kuhlmann , Gustavo Pereira de Almeida, Kristiyan Kanev, Christine Wurmser , Ann-Katrin Gerullis , Patrick Roelli , Jacqueline Berner and Dietmar Zehn (4 Nov 2022) Secondary infections rejuvenate the intestinal CD103+ tissue-resident memory T cell pool. Science Immunology 7(77). DOI: 10.1126/sciimmunol.abp9553 (Project B14)

Manfred B Lutz, Shafaqat Ali, Cindy Audiger, Stella E Autenrieth, Luciana Berod , Venetia Bigley, Laura Cyran , Marc Dalod, Jan Dörrie, Diana Dudziak, Georgina Flórez-Grau, Lucila Giusiano, Gloria J Godoy, Marion Heuer, Anne B Krug, Christian H K Lehmann, Christian T Mayer, Shalin H Naik, Stefanie Scheu, Gerty Schreibelt, Elodie Segura, Kristin Seré, Tim Sparwasser, Jurjen Tel, Huaming Xu, Martin Zenke (2022 Oct 27) Guidelines for mouse and human DC generation. Eur J Immunol. doi: 10.1002/eji.202249816. PMID: 36303448 (Project A06)

Rebecca Metzger, Lis Winter , Nassim Bouznad, Debora Garzetti, Benedikt von Armansperg, Matjaz Rokavec, Konstantin Lutz, Yvonne Schäfer, Sabrina Krebs, Elena Winheim, Verena Friedrich, Dana Matzek, Rupert Öllinger, Roland Rad, Bärbel Stecher, Heiko Hermeking, Thomas Brocker, Anne B Krug (2022 Oct 17:ji2100867) CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota. J Immunol. Online ahead of print. doi: 10.4049/jimmunol.2100867. PMID: 36253052 (Projects A06, B03)

Felix J. Metzner, Simon J. Wenzl; Michael Kugler, Stefan Krebs, Karl-Peter Hopfner & Katja Lammens (2022 Sept 17) Mechanistic understanding of human SLFN11. Nat Commun 13, 5464 (2022). https://doi.org/10.1038/s41467-022-33123-0 (Project B02)

Thorsten R Mempel and Daniel Krappmann (2022 Sept 17) Combining precision oncology and immunotherapy by targeting the MALT1 protease. Journal for ImmunoTherapy of Cancer. 10:e005442. doi:10.1136/jitc-2022-005442 (Project A04)

Hohle MM, Lammens K, Gut F, Wang B, Kahler S, Kugler K, Till M, Beckmann R, Hopfner KP, Jung C (2022 Sep 12) Ice thickness monitoring for cryo-EM grids by interferometry imaging. Sci Rep. 12(1):15330. doi: 10.1038/s41598-022-16978-7. PMID: 36097274 (Project B02)

Fabian Gut, Lisa Käshammer, Katja Lammens, Joseph D. Bartho, Anna-Maria Buggusch, Erik van de Logt, Brigitte Kessler, Karl-Peter Hopfner (19 Aug 2022) Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50. Molecular Cell 82: 1-10. https://doi.org/10.1016/j.molcel.2022.07.019 (Project B02)

Carlson Tsui, Lornez Kretschmer, Svenja Rapelius, Sarah S. Gabriel, David Chisanga, Konrad Knöpper, Daniel T. Utzschneider, Simone Nüssing, Yang Liao, Teisha Mason, Santiago Valle Torres, Stephen A. Wilcox, Krystian Kanev, Sebastian Jarosch, Justin Leube, Stephen L. Nutt, Dietmar Zehn, Ian A. Parish, Wolfgang Kastenmüller, Wei Shi, Veit R. Buchholz & Axel Kallies (17 Aug 2022) MYB orchestrates T cell exhaustion and response to checkpoint inhibition. Nature. https://doi.org/10.1038/s41586-022-05105-1 (Projects B15, B14)

Anna Purcarea, Sebastian Jarosch, Jack Barton, Simon Grassmann, Ludwig Pachmayr, Elvira D’Ippolito, Monika Hammel, Anna Hochholzer, Karolin I. Wagner, Joost H. van den Berg, Veit R. Buchholz, John B.A.G. Haanen, Dirk H. Busch and Kilian Schober (12 Aug 2022) Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity. Science Immunology Vol 7, Issue 74 DOI: 10.1126/sciimmunol.abm2077 (Projects B09 and B15)

Alisha N Jones, Carina Graß, Isabel Meininger, Arie Geerlof, Melina Klostermann, Kathi Zarnack, Daniel Krappmann, Michael Sattler (2022 Aug 5) Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1. Science Advances 8(31):eabp9153. doi: 10.1126/sciadv.abp9153. (Project A04)

Ito-Kureha T, Leoni C, Borland K, Cantini G, Bataclan M, Metzger RN, Ammann G, Krug AB, Marsico A, Kaiser S, Canzar S, Feske S, Monticelli S, König J, Heissmeyer V. (2022) The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells. Nat Immunol. Aug 2022;23(8):1208-1221. doi: 10.1038/s41590-022-01268-1. Epub 2022 Jul 25. PMID: 35879451 (Projects A03, A06)

Meike Mitsdoerffer, Lilian Alya, Melanie Barz, Thomas Engleitner, Christopher Sie, Claire Delbridge, Gildas Lepennetier, Rupert Öllinger, Monika Pfaller , Benedikt Wiestler, Roland Rad, Bernhard Meyerc, Benjamin Knier , Friederike Schmidt-Graf, Jens Gempt and Thomas Korn (July 2022) The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the TH17 lineage in humans. PNAS 119(34) e2206208119. https://doi.org/10.1073/pnas.2206208119 (Project B06)

Konstantin Lutz, Andrea Musumeci, Christopher Sie, Ezgi Dursun, Elena Winheim, Johannes Bagnoli, Christoph Ziegenhain, Lisa Rausch, Volker Bergen, Malte D. Luecken, Robert A. J. Oostendorp, Barbara U. Schraml, Fabian J. Theis, Wolfgang Enard, Thomas Korn & Anne B. Krug. Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage. Nat Commun 13, 3456 (2022). https://doi.org/10.1038/s41467-022-31054-4 PMID: 35705536; PMCID: PMC9200809 (Projects A06, B06)

Sie C, Kant R, Peter C, Muschaweckh A, Pfaller M, Nirschl L, Domínguez Moreno H, Chadimová T, Lepennetier G, Kuhlmann T, Öllinger R, Engleitner T, Rad R & Korn T. (2022) IL-24 intrinsically regulates Th17 cell pathogenicity in mice. Journal of Experimental Medicine 219 (8): e20212443. https://doi.org/10.1084/jem.20212443. (Project B06)

Dietmar Zehn, Robert Thimme, Enrico Lugli, Gustavo Pereira de Almeida, Annette Oxenius (27 May 2022) 'Stem-like' precursors are the fount to sustain persistent CD8 + T cell responses. Review. Nature Immunology 23(6): 836-847 doi: 10.1038/s41590-022-01219-w. (Project B14)

R. Kaiser, R. Escaig, J. Kranich, M. L. Hoffknecht, A. Anjum, V. Polewka, M. Mader, W. Hu, L. Belz, C.Gold, A. Titova, M. Lorenz, K. Pekayva, St. Kääb, F. Gaertner, K. Stark, T. Brocker, S. Massberg, L. Nicolai (April 26, 2022) Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI. Blood. Accession Number: 35472164 DOI: 10.1182/blood.2021014914 (Project B03)

S. Stutte, H. Ishikawa-Ankerhold, L. Lynch, S. Eickhoff, S. Nasiscionyte, C. Guo, D. van den Heuvel, D. Setzensack, M. Colonna, D. Maier-Begandt, L. Weckbach, T. Brocker, C.Schulz, B. Walzog, U van Andrian (Feb 18, 2022) High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue. J Immunol (Vol. 208 Issue 6) Pages 1445-1455. Accession Number: 35181637 PMCID: PMC8919350 DOI: 10.4049/jimmunol.2100022 (Project B03)

Hongli Yin, Ozge Karayel, Ying-Yin Chao, Thomas Seeholzer, Isabel Hamp, Oliver Plettenburg, Torben Gehring, Christina Zielinski, Matthias Mann & Daniel Krappmann (2022) A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells. Cellular and Molecular Life Sciences volume 79, Article number: 112. DOI: https://doi.org/10.1007/s00018-022-04154-z (Projects A04, B10)

Gustavo P. De Almeida, Peter Lichtner, Gertrud Eckstein, Tonio Brinkschmidt, Chang-Feng Chu, Shan Sun, Julian Reinhard, Sophia C. Mädler, Markus Kloeppel, Mareike Verbeek and Christina Zielinski (28 Jan 2022) Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential. Science Immunology (Vol 7, Issue 67). DOI: 10.1126/sciimmunol.abe2634 (Project B10)

Felix J Metzner, Elisabeth Huber, Karl-Peter Hopfner, Katja Lammens (17 January 2022) Structural and biochemical characterization of human Schlafen 5. Nucleic Acids Research, gkab1278, https://doi.org/10.1093/nar/gkab1278 (Project B02)