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Publications 2019

Sie, C., Perez, L.G., Kreutzfeldt, M., Potthast, M., Ohnmacht, C., Merkler, D., Huber, S., Krug, A., and Korn, T. (2019). Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins. J. Immunol. 203, 1417–1427. doi: 10.4049/jimmunol.1900468. [Projects A06 and B06]

Scherm, M.G., Serr, I., Zahm, A.M., Schug, J., Bellusci, S., Manfredini, R., Salb, V.K., Gerlach, K., Weigmann, B., Ziegler, A.G., Kaestner, K., and Daniel, C. (2019). miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes. Nat. Commun. 10, 1–15. doi: 10.1038/s41467-019-13587-3. [Project B11]

Lowe, M.M., Boothby, I., Clancy, S., Ahn, R.S., Liao, W., Nguyen, D.N., Schumann, K., Marson, A., Mahuron, K.M., Kingsbury, G.A., Liu, Z., Munoz Sandoval, P., Sanchez Rodriguez, R., Pauli, M.L., Taravati, K., Arron,S.T., Neuhaus, I.M., Harris, H.W., Kim, E.A., Shin, U.S., Krummel, M.F., Daud, A., Scharschmidt, T.C., and Rosenblum, M.D. (2019). Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight 4. doi: 10.1172/jci.insight.129756. [Project AP03]

Andreas, N., Potthast, M., Geiselhöringer, A.-L., Garg, G., de Jong, R., Riewaldt, J., Russkamp, D., Riemann, M., Girard, J.-P., Blank, S., Kretschmer, K., Schmidt-Weber, C., Korn, T., Weih, F., and Ohnmacht, C. (2019). RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells. J. Immunol. 203, 2602–2613. doi: 10.4049/jimmunol.1801530. [Project B06]

Korn, T., and Muschaweckh, A. (2019). Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments. Front. Immunol. 10, 1–8. doi: 10.3389/fimmu.2019.02634. [Project B06]

Käshammer, L., Saathoff, J.-H., Lammens, K., Gut, F., Bartho, J., Alt, A., Kessler, B., and Hopfner, K.-P. (2019). Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex. Mol. Cell 76, 382–394. doi: 10.1016/j.molcel.2019.07.035. [Project B02]

Somekh, I., Thian, M., Medgyesi, D., Gülez, N., Magg, T., Duque, A.G., Stauber, T., Lev, A., Genel, F., Unal, E., Simon, A.J., Lee, Y.N., Kalinichenko, A., Dmytrus, J., Kraakman, M. J., Schiby, G., Rohlfs, M., Jacobsen, J.M., Özer, E., Akcal, Ö., Canco, R., Patiroglu, T., Karakukcu, M., Ozcan, A., Shahin, T., Appella, E., Tatematsu, M., Martinez-Jaramillo, C:, Chinn, I.K., Orange, J.S., Trujillo-Vargas, C.M., Franco, J.L., Hauck, F., Somech, R., Klein, C., and Boztug, K. (2019). CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis. Blood 134, 1510–1516. doi: 10.1182/blood.2019000644. [Project A05]

Gehring, T., Erdmann, T., Rahm, M., Graß, C., Flatley, A., O’Neill, T.J., Woods, S., Meininger, I., Karayel, O., Kutzner, K., Grau, M., Shinohara, H., Lammens, K., Feederle, R., Hauck, S.M., Lenz, G., and Krappmann, D. (2019). MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. Cell Rep. 29, 873-888.e10. doi: 10.1016/j.celrep.2019.09.040. [Project A04 and B02]

Tavernier, S.J., Athanasopoulos, V., Verloo, P., Behrens, G., Staal, J., Bogaert, D.J., Naesens, L., De Bruyne, M., Van Gassen, S., Parthoens, E., Ellyard, J., Cappello, J., Morris, L.X., Van Gorp, H., Van Isterdael, G., Saeys, Y., Lamkanfil, M., Schelstraete, P., Dehoorne, J., Bordon, V., Van Coster, R., Lambrecht, B.N., Menten, B., Beyaert, R., Vinuesa, C.G., Heissmeyer, V., Dullaers, M., and Haerynck, F. (2019). A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation. Nat. Commun. 10. doi: 10.1038/s41467-019-12704-6. [Project A03]

Magg, T., Shcherbina, A., Arslan, D., Desai, M.M., Wall, S., Mitsialis, V., Conca, R., Unal, E., Karacabey, N., Mukhina, A., Rodina, Y., Taur, P.D., Illig, D., Marquardt, B., Hollizek, S., Jeske, T., Gothe, F., Schober, T., Rohlfs, M., Koletzko, S., Lurz, E., Muise, A.M., Snapper, S.B., Hauck, F., Klein, C., and Kotlarz, D. (2019). CARMIL2 Deficiency Presenting as Very Early Onset Inflammatory Bowel Disease. Inflamm. Bowel Dis. 25, 1788–1795. doi: 10.1093/ibd/izz103. [Project A05]

Metzger, R., Maruskova, M., Krebs, S., Janssen, K.P., and Krug, A.B. (2019). Increased Incidence of Colon Tumors in AOM-Treated Apc1638N/+ Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine. Front. Oncol. 9, 1–12. doi: 10.3389/fonc.2019.01001. [Project A06]

Kanev, K., Wu, M., Drews, A., Roelli, P., Wurmser, C., von Hösslin, M., and Zehn, D. (2019). Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent. Proc. Natl. Acad. Sci. U. S. A. 116, 20070–20076. doi: 10.1073/pnas.1902701116. [Project B14]

Fecher, C., Trovò, L., Müller, S.A., Snaidero, N., Wettmarshausen, J., Heink, S., Ortiz, O., Wagner, I., Kühn, R., Hartmann, J., Karl, R.M., Konnerth, A., Korn, T., Wurst, W., Merkler, D., Lichtenthalter, S.F., Perocchi, F., and Misgeld, T. (2019). Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nat. Neurosci. 22, 1731–1742. doi: 10.1038/s41593-019-0479-z. [Project B06]

Becker, M., Serr, I., Salb, V.K., Ott, V.B., Mengel, L., Blüher, M., Weigmann, B., Hauner, H., Tschöp, M.H., and Daniel, C. (2019). Short-term cold exposure supports human Treg induction in vivo. Mol. Metab. 28, 73–82. doi: 10.1016/j.molmet.2019.08.002. [Project B11]

Hassler, T., Urmann, E., Teschner, S., Federle, C., Dileepan, T., Schober, K., Jenkins, M.K., Busch, D.H., Hinterberger, M., and Klein, L. (2019). Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors. Proc. Natl. Acad. Sci. U. S. A. 116, 18537–18543. doi: 10.1073/pnas.1907615116 [Projects A01 and B09]

Li, K., Neumann, K., Duhan, V., Namineni, S., Hansen, A.L., Wartewig, T., Kurgyis, Z., Holm, C.K., Heikenwalder, M., Lang, K.S., and Ruland, J. (2019a). The uric acid crystal receptor Clec12A potentiates type I interferon responses. Proc. Natl. Acad. Sci. U. S. A. 116, 18544–18549. doi: 10.1073/pnas.1821351116. [Project B01]

Matthias, J., and Zielinski, C.E. (2019). Shaping the diversity of Th2 cell responses in epithelial tissues and its potential for allergy treatment. Eur. J. Immunol. 49, 1321–1333. doi: 10.1002/eji.201848011. [Project B10]

Palit, S., Heuser, C., De Almeida, G.P., Theis, F.J., and Zielinski, C.E. (2019). Meeting the challenges of high-dimensional single-cell data analysis in immunology. Front. Immunol. 10, 1–12. doi: 10.3389/fimmu.2019.01515. [Project B10]

Raulf, M.K., Johannssen, T., Matthiesen, S., Neumann, K., Hachenberg, S., Mayer-Lambertz, S., Steinbeis, F., Hegermann, J., Seeberger, P.H., Baumgärtner, W., Strube, C., Ruland, J., and Lepenies, B.. (2019). The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development. Cell Rep. 28, 30-38.e5. doi: 10.1016/j.celrep.2019.06.015. [Project B01]

von Gamm, M., Schaub, A., Jones, A.N., Wolf, C., Behrens, G., Lichti, J., Essig, K., Macht, A., Pircher, J., Ehrlich, A., Davari, K., Chauhan, D., Busch, B., Wurst, W., Feederle, R., Feuchtinger, A., Tschöp, M.H., Friedel, C.C., Hauck, S.M., Sattler, M., Geerlof, A., Hornung V., Heissmeyer, V., Schulz, C., Heikenwalder, M., and Glasmacher, E. (2019). Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. J. Exp. Med. 216, 1700–1723. doi: 10.1084/jem.20181762. [Project A03]

Alfei, F., Kanev, K., Hofmann, M., Wu, M., Ghoneim, H.E., Roelli, P., Utzschneider, D.T., von Hoesslin, M., Cullen, J.G., Fan, Y., Eisenberg, V., Wohlleber, D., Steiger, K., Merkler, D., Delorenzi, M., Knolle, P.A., Cohen, C.J., Thimme, R., Youngblood, B., and Zehn, D. (2019). TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection. Nature 571, 265–269. doi: 10.1038/s41586-019-1326-9. [Project B14]

Failmezger, H., Dursun, E., Dümcke, S., Endele, M., Poron, D., Schroeder, T., Krug, A., and Tresch, A. (2019). Clustering of samples with a tree-shaped dependence structure, with an application to microscopic time lapse imaging. Bioinformatics 35, 2291–2299. doi: 10.1093/bioinformatics/bty939. [Project A06]

Grassmann, S., Pachmayr, L.O., Leube, J., Mihatsch, L., Andrae, I., Flommersfeld, S., Oduro, J., Cicin-Sain, L., Schiemann, M., Flossdorf, M., and Buchholz, V.R. (2019). Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection. Immunity 50, 1391-1400.e4. doi: 10.1016/j.immuni.2019.04.015. [Project B09]

Musumeci, A., Lutz, K., Winheim, E., and Krug, A.B. (2019). What makes a pDC: Recent advances in understanding plasmacytoid DC development and heterogeneity. Front. Immunol. 10, 1–7. doi: 10.3389/fimmu.2019.01222. [Project A06]

Rosenbaum, M., Gewies, A., Pechloff, K., Heuser, C., Engleitner, T., Gehring, T., Hartjes, L., Krebs, S., Krappmann, D., Kriegsmann, M., Weichert, W., Rad, R., Kurts, C., and Ruland, J. (2019). Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat. Commun. 10. doi: 10.1038/s41467-019-10203-2. [Projects A04 and B01]

Yamano, T., Dobeš, J., Vobořil, M., Steinert, M., Brabec, T., Zietara, N., Dobešová, M., Ohnmacht, C., Laan, M., Peterson, P., Benes, V., Sedláček, R., Hanayama, R., Kolář, M., Klein, L., and Filipp, D. (2019). Aire-expressing ILC3-like cells in the lymph node display potent APC features. J. Exp. Med. 216, 1027–1037. doi: 10.1084/jem.20181430. [Project A01]

Wartewig, T., and Ruland, J. (2019). PD-1 Tumor Suppressor Signaling in T Cell Lymphomas. Trends Immunol. 40, 403–414. doi: 10.1016/j.it.2019.03.005. [Project B01]

Dashtsoodol, N., Bortoluzzi, S., and Schmidt-Supprian, M. (2019). T cell receptor expression timing and signal strength in the functional differentiation of invariant natural killer T cells. Front. Immunol. 10, 1–8. doi: 10.3389/fimmu.2019.00841. [Project A02]

Markó, L., Park, J.-K., Henke, N., Rong, S., Balogh, A., Klamer, S., Bartolomaeus, H., Wilck, N., Ruland, J., Forslund, S.K., Luft, F.C., Dechend, R., and Müller, D.N. (2019). B-cell lymphoma/leukaemia 10 and angiotensin II-induced kidney injury. Cardiovasc. Res. 116, 1059-1070. doi: 10.1093/cvr/cvz169. [Project B01]

Albers, J.J., Ammon, T., Gosmann, D., Audehm, S., Thoene, S., Winter, C., Secci, R., Wolf, A., Stelzl, A., Steiger, K., Ruland, J., Bassermann, F., Kupatt, C., Anton, M., and Krackhardt, A.M. (2019). Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection. Life Sci. Alliance 2, 1–10. doi: 10.26508/lsa.201900367. [Project B01]

Maul, J., Alterauge, D., and Baumjohann, D. (2019). MicroRNA-mediated regulation of T follicular helper and T follicular regulatory cell identity. Immunol. Rev. 288, 97–111. doi: 10.1111/imr.12735. [Project B12]

Hartjes, L., and Ruland, J. (2019). CARD9 signaling in intestinal immune homeostasis and oncogenesis. Front. Immunol. 10, 1–7. doi: 10.3389/fimmu.2019.00419. [Project B01]

Matthias, J., Maul, J., Noster, R., Meinl, H., Chao, Y.Y., Gerstenberg, H., Jeschke, F., Gasparoni, G., Welle, A., Walter, J., Nordström, K., Eberhardt, K., Renisch, D., Donakonda, S., Knolle, P., Soll, D., Grabbe, S., Garzorz-Stark, N., Eyerich, K., Biedermann, T. Baumjohann, D. and Zielinski, C. (2019). Sodium chloride is an ionic checkpoint for human T H 2 cells and shapes the atopic skin microenvironment. Sci. Transl. Med. 11, 1–12. doi: 10.1126/scitranslmed.aau0683. [Projects B10 and B12]

Feucht, N., Maier, M., Lepennetier, G., Pettenkofer, M., Wetzlmair, C., Daltrozzo, T., Scherm, P., Zimmer, C., Hoshi, M.M., Hemmer, B., Korn, T., and Knier, B. (2019). Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis. Mult. Scler. J. 25, 224–234. doi: 10.1177/1352458517750009. [Project B06]

Illig, D., Navratil, M., Kelečić, J., Conca, R., Hojsak, I., Jadrešin, O., Ćorić, M., Vuković, J., Rohlfs, M., Hollizeck, S., Bohne, J., Klein, C., and Kotlarz, D. (2019). Alternative Splicing Rescues Loss of Common Gamma Chain Function and Results in IL-21R-like Deficiency. J. Clin. Immunol. 39, 207–215. doi: 10.1007/s10875-019-00606-7. [Project A05]

Ruland, J., and Hartjes, L. (2019). CARD–BCL-10–MALT1 signalling in protective and pathological immunity. Nat. Rev. Immunol. 19, 118–134. doi: 10.1038/s41577-018-0087-2. [Project B01]

Garg, G., Muschaweckh, A., Moreno, H., Vasanthakumar, A., Floess, S., Lepennetier, G., Oellinger, R., Zhan, Y., Regen, T., Hiltensperger, M., Peter, C., Aly, L., Knier, B., Palam, L.R., Kapur, R., Kaplan, M.H., Waismann, A., Rad, R., Schotta, G., Huehn, J., Kallies, and Korn, T. (2019). Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation. Cell Rep. 26, 1854-1868.e5. doi: 10.1016/j.celrep.2019.01.070. [Project B06]

Zwick, M., Ulas, T., Cho, Y.L., Ried, C., Grosse, L., Simon, C., Bernhard, C., Busch, D.H., Schultze, J.L., Buchholz, V.R., Stutte, S., Brocker T. (2019). Expression of the phosphatase PPEF2 controls survival and function of CD8+ dendritic cells. Front. Immunol. 10, 1–15. doi: 10.3389/fimmu.2019.00222. [Projects B03 and B09]

Cho, J.J., Xu, Z., Parthasarathy, U., Drashansky, T.T., Helm, E.Y., Zuniga, A.N., Lorentsen, K.J., Mansouri, S., Cho, J.Y., Edelmann, M.J., Duong, D.M., Gehring, T., Seeholzer, T., Krappmann, D., Uddin, M.N., Califano, D., Wang, R.L., Jin, L., Li, H., Lv, D., Zhou, D., Zhou, L., and Avram, D. (2019). Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Nat. Commun. 10, 1–18. doi: 10.1038/s41467-019-08605-3. [Project A04]

Lehle, A.S., Farin, H.F., Marquardt, B., Michels, B.E., Magg, T., Li, Y., Liu, Y., Ghalandary, M., Lammens, K., Hollizeck, S., Rohlfs, M., Hauck, F., Conca, R., Walz, C., Weiss, B., Lev, A., Simon, A.J., Groß, O., Gaidt, M.M., Hornung, V., Clevers, H., Yazbeck, N., Hanna-Wakim, R., Shouval, D.S., Warner, N., Somech, R., Muise, A.M., Snapper, S.S., Bufler, P., Koletzko, S., Klein, C., and Kotlarz, D. (2019). Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency. Gastroenterology 156, 275–278. doi: 10.1053/j.gastro.2018.09.041. [Project A05]

Klein, L., Robey, E.A., and Hsieh, C.S. (2019). Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation. Nat. Rev. Immunol. 19, 7–18. doi: 10.1038/s41577-018-0083-6. [Project A01]

Korn, T. (2019). Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues. Cell 176, 416–418. doi: 10.1016/j.cell.2018.12.025. [Project B06]

Ogrinc Wagner, A., Friedrich, V., Barthels, C., Marconi, P., Blutke, A., Brombacher, F., and Brocker, T. (2019). Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis. PLoS One 14, 1–20. doi: 10.1371/journal.pone.0210998. [Project B03]

Li, Y., Führer, M., Bahrami, E., Socha, P., Klaudel-Dreszler, M., Bouzidi, A., Liu, Y., Lehle, A.S., Magg, T., Hollizeck, S., Rohlfs, M., Conca, R., Field, M., Warner, N., Mordechai, S., Shteyer, E., Turner, D., Boukari, R., Belbouab, R., Walz, C., Gaidt, M.M., Hornung, V., Baumann, B., Pannicke, U., Al Adrissi, E., Alghamdi, H.A., Sepulveda, F.E., Gil, M., de Saint Basile, G., Hönig, M., Koletzko, S., Muise, A.M., Snapper, S.B., Schwarz, K., Klein, C., and Kotlarz, D. (2019b). Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases. Proc. Natl. Acad. Sci. U. S. A. 116, 970–975. doi: 10.1073/pnas.1813582116. [Project A05]

Hultquist, J.F., Hiatt, J., Schumann, K., McGregor, M.J., Roth, T.L., Haas, P., Doudna, J.A., Marson, A., and Krogan, N.J. (2019). CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions. Nat. Protoc. 14. 1-27. doi: 10.1038/s41596-018-0069-7. [Project AP03]

 


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