Publications

2024

Carina Diehl, Valeria Soberón,  Seren Baygün, Yuanyuan Chu, Jonathan Mandelbaum, Laura Kraus, Thomas Engleitner,∙ Martina Rudelius,∙ Marco Fangazio, ∙ Christoph Daniel, ∙ Sabrina Bortoluzzi, ∙ Sabine Helmrath, ∙ Pankaj Singroul, ∙ Vanessa Gölling, ∙ Francisco Osorio Barrios, ∙ Gönül Seyhan, ∙ Lena Oßwald, ∙ Maike Kober-Hasslacher, ∙ Theodor Zeng, ∙ Rupert Öllinger, ∙ Ali M. Afzali, ∙ Thomas Korn,∙ Mohsen Honarpisheh, ∙ Maciej Lech, ∙ Qurrat Ul Ain, ∙ Joachim Pircher, ∙ Vanna Imširović, ∙ Vedrana Jelenčić, ∙ Felix M. Wensveen, ∙ Verena Passerini, ∙ Stefanie Bärthel, ∙ Govind Bhagat, ∙ David Dominguez-Sola,∙ Dieter Saur, ∙ Katja Steiger, ∙ Roland Rad,∙ Laura Pasqualucci, ∙ Oliver Weigert, ∙ Marc Schmidt-Supprian (2024 Dec 26) Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesi. Immunity S1074-7613(24)00538-7. doi: 10.1016/j.immuni.2024.11.023 (Projects A02, B06)

Maryam Kazerani, Filippo Cernilogar, Alessandra Pasquarellaa, Maria Hinterberger, Alexander Nuber, Ludger Klein, and Gunnar Schotta (2024 Dec 17) Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers. PNAS 121(52) e2409656121. https://doi.org/10.1073/pnas.2409656121 (Project A01)

Laurenz T. Ursch, Jule S. Müschen, Julia Ritter, Julia Klermund, Bettina E. Bernard, Saskia Kolb, Linda Warmuth, Geoffroy Andrieux, Gregor Miller, Marina Jiménez-Muñoz, Fabian J. Theis, Melanie Boerries, Dirk H. Busch, Toni Cathomen and Kathrin Schumann (2024 Dec 17) Modulation of TCR stimulation and pifithrin-a improves the genomic safety profile of CRISPR-engineered human T cells. Cell Reports Medicine 5, 101846. DOI: 10.1016/j.xcrm.2024.101846 (Projects B09, B16)

Lavinia Flaskamp, Monica Prechtl, Annkathrin Scheck, Wenbo Hu, Christine Ried, Georg Kislinger, Mikael Simons, Anne Krug, Jan Kranich, Thomas Brocker (2024 Nov 14) Assessing Extracellular Vesicle Turnover In vivo Using Highly Sensitive Phosphatidylserine-Binding Reagents. bioRxiv. doi: https://doi.org/10.1101/2024.11.14.623541 (Projects A06, B03, Z02)

Rosenlehner, T., Pennavaria, S., Akcabozan, B., Jahani, S., O'Neill, T. J., Krappmann, D., Straub, T., Kranich, J. and Obst, R., (2024 Oct 22) Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells. Sci Signal 2024. 17: eadi8753. DOI: 10.1126/scisignal.adi8753 (link) (Projects A04, Z02)

Dominik Soll, Chang-Feng Chu, Shan Sun, Veronika Lutz, Mahima Arunkumar, Mariam Gachechiladze, Sascha Schäuble, Maha Alissa-Alkhalaf, Trang Nguyen, Michelle-Amirah Khalil, Ignacio Garcia-Ribelles, Michael Mueller, Katrin Buder, Bernhard Michalke, Gianni Panagiotou, Kai Ziegler-Martin, Pascal Benz, Philipp Schatzlmaier, Karsten Hiller, Hannes Stockinger, Maik Luu, Kilian Schober, Carolin Moosmann, Wolfgang W. Schamel, Magdalena Huber & Christina E. Zielinski (2024 Aug 28) Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity. Nature Immunology. DOI: https://doi.org/10.1038/s41590-024-01918-6 (Projects B09, B10)

Florian Gaertner, Hellen Ishikawa-Ankerhold, Susanne Stutte, Wenwen Fu, Jutta Weitz, Anne Dueck, Bhavishya Nelakuditi, Valeria Fumagalli, Dominic van den Heuvel, Larissa Belz, Gulnoza Sobirova, Zhe Zhang, Anna Titova, Alejandro Martinez Navarro, Kami Pekayvaz, Michael Lorenz, Louisa von Baumgarten, Jan Kranich, Tobias Straub, Bastian Popper, Vanessa Zheden, Walter Anton Kaufmann, Chenglong Guo, Guido Piontek, Saskia von Stillfried, Peter Boor, Marco Colonna, Sebastian Clauß, Christian Schulz, Thomas Brocker, Barbara Walzog, Christoph Scheiermann, William C. Aird, Claus Nerlov, Konstantin Stark, Tobias Petzold, Stefan Engelhardt, Michael Sixt, Robert Hauschild, Martina Rudelius, Robert A. J. Oostendorp, Matteo Iannacone, Matthias Heinig & Steffen Massberg (2024 Jul 10) Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. Nature 631, 645-653. https://doi.org/10.1038/s41586-024-07671-y (Project B03)

Bahareh Nemati Moud, Franziska Ober, Thomas J. O’Neill and Daniel Krappmann (2024 May 28) MALT1 substrate cleavage: what is it good for? Front Immunol 15: 1412347. doi: 10.3389/fimmu.2024.1412347 (Project A04)

Stephanie Musiol, Carla P. Harris, Silvia Gschwendtner, Amy Burrell, Yacine Amar, Benjamin Schnautz, Dennis Renisch, Sonja C. Braun,
Stefan Haak, Michael Schloter, Carsten B. Schmidt-Weber, Christina E. Zielinski, Francesca Alessandrini (2024 Apr 14) The impact of high-salt diet on asthma in humans and mice: Effect on specific T-cell signatures and microbiome. Allergy 00: 1-14. DOI: 10.1111/all.16148

Meng Xu, Taku Ito-Kureha, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai P. Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, and Vigo Heissmeyer (2024 Mar 11) The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression. Nat Commun. 15:2194. Doi: 10.1038/s41467-024-46371-z (Projects A03, B11)

Yinshui Chang, Luisa Bach, Marko Hasiuk, Lifen Wen, Tarek Elmzzahi, Carlson Tsui, Nicolás Gutiérrez-Melo, Teresa Steffen, Daniel T Utzschneider, Timsse Raj, Paul Jonas Jost, Sylvia Heink, Jingyuan Cheng, Oliver T Burton, Julia Zeiträg, Dominik Alterauge, Frank Dahlström, Jennifer-Christin Becker, Melanie Kastl, Konstantinos Symeonidis, Martina van Uelft, Matthias Becker, Sarah Reschke, Stefan Krebs , Helmut Blum, Zeinab Abdullah, Katrin Paeschke, Caspar Ohnmacht, Christian Neumann, Adrian Liston, Felix Meissner, Thomas Korn, Jan Hasenauer, Vigo Heissmeyer, Marc Beyer, Axel Kallies, Lukas T Jeker, Dirk Baumjohann (2024 Mar 1) TGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf. Sci Immunol 9(93):eadd4818. doi: 10.1126/sciimmunol.add4818 (Projects A03, B06)

Antonio Santos-Peral, Fabian Luppa, Sebastian Goresch, Elena Nikolova, Magdalena Zaucha, Lisa Lehmann, Frank Dahlstroem, Hadi Karimzadeh, Julia Thorn-Seshold, Elena Winheim, Ev-Marie Schuster, Gerhard Dobler, Michael Hoelscher, Beate M. Kümmerer, Stefan Endres, Kilian Schober, Anne B. Krug, Michael Pritsch, Giovanna Barba-Spaeth & Simon Rothenfusser (2024 Feb 24) Prior flavivirus immunity skews the yellow fever vaccine response to cross-reactive antibodies with potential to enhance dengue virus infection. Nature Communications 15:1696. https://doi.org/10.1038/s41467-024-45806-x. (Projects A06, B09)

Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov, Tobias Hassler, Christine Federle, Elisabetta Petrozziello, Sudhakar Reddy Kalluri, Hsin Hsiang Chen, Sofia Tyystjärvi, Andreas Muschaweckh, Katja Lammens, Claire Delbridge, Andreas Büttner, Katja Steiger, Gönül Seyhan, Ole Petter Ottersen, Rupert Öllinger, Roland Rad, Sebastian Jarosch, Adrian Straub, Anton Mühlbauer, Simon Grassmann, Bernhard Hemmer, Jan P. Böttcher, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Irene Bonafonte Pardàs, Marc Schmidt Supprian, Veit R. Buchholz, Sylvia Heink, Dirk H. Busch, Ludger Klein & Thomas Korn (2024 Feb 21) B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature. https://doi.org/10.1038/s41586-024-07079-8 (Projects A01, A02, B02, B06, B09, B15)

Maike Becker, Sandra M. Dirschl, Martin G. Scherm, Isabelle Serr, Carolin Daniel (2024 Feb 6) Niche-specific control of tissue function by regulatory T cells—Current challenges and perspectives for targeting metabolic disease. Cell Metabolism 36(2) 229-239. https://doi.org/10.1016/j.cmet.2023.12.019 (Project B11)

Marie J. Tofaute, Benjamin Weller, Carina Graß, Hridi Halder, Bushra Dohai, Pascal Falter-Braun and Daniel Krappmann (2024 Jan 09) SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation. Bioscience Reports 44 BSR20231418. https://doi.org/10.1042/BSR20231418 (Project A04)