News

08.01.2025

Precursors of exhausted T cells are preemptively formed in acute infection

Nature article from the Zehn lab more
31.12.2024

Season's Greetings, Best Wishes and Farewell

After 12 succsessful years, the SFB 1054 ends on December 31, 2024 more
26.12.2024

Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis

Immunity article from the Schmidt-Supprian lab, with first author IRTG member Carina Diehl more
17.12.2024

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers

PNAS article with contribution from the Klein lab (A01) more
17.12.2024

Modulation of TCR stimulation and pifithrin-a improves the genomic safety profile of CRISPR- engineered human T cells

Cell Reports Medicine article (in press) from the Schumann lab more
03.12.2024

Christina Zielinski is awarded ERC Consolidator Grant

Supporting scholars and researchers across Europe more
26.11.2024

IRTG 1054 Wrap-up Meeting and Alumni Get-Together

A final meeting for reflection, inspiration and team reinforcement more
14.11.2024 at 12:30

Eva-Maria Albers: Extracellular vesicles in CNS homeostasis – from axonal maintenance to physical and mental stress

Institut für Entwicklungs- und Neurobiologie, JGU Mainz more
02.10.2024

Trailblazer Lecture with Muzlifah Haniffa

Co-hosted by the CRC 1054, TRR 359 and the BMC more
01.10.2024

Biotech & Pharma Career Day 2024

Meet biotech and pharma companies from the greater Munich area more
25.09.2024

Diversity, Identity & Fate at Biomedical Frontiers

Symposium on diversity in research and in the people who do the research – SAVE the DATE more
22.09.2024 – 27.09.2024

ImmunOctoberfest 2024

Bridging Innovation and Translation in T cell Immunotherapy more
28.08.2024

Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity

Nature Immunology article from the Zielinski lab (B10) more
25.07.2024

Responsible Research 2024

A campus-wide event for next-generation researchers more
10.07.2024

Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis

Nature article with contribution from Jan Kranich and Thomas Brocker (B03) more
06.07.2024

Monica Prechtl gets up on her soapbox!

Public outreach for women scientists – co-sponsored by the SFB 1054! more
28.05.2024

MALT1 substrate cleavage: what is it good for?

Frontiers in Immunology review article from the Krappmann lab (A04) more
14.04.2024

The impact of high-salt diet on asthma in humans and mice: Effect on specific T-cell signatures and microbiome

Allergy article with contribution from the Zielinski lab more
11.04.2024 at 12:30

Sarah Kim-Hellmuth: Understanding the effects of genetic diversity on the human immune system

Dr. von Haunsches Kinderspital München and HGMU Institute of Translational Genomics more
11.03.2024

The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression

Nature Communications article with co-corresponding author Vigo Heissmeyer more
01.03.2024

TGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf

Science Immunology article with contributions from the Korn, Heissmeyer and Baumjohann labs more
24.02.2024

Prior flavivirus immunity skews the yellow fever vaccine response to cross-reactive antibodies with potential to enhance dengue virus infection

Nature Communications article with contribution from the Schober and Krug labs more
21.02.2024

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4

Nature article from a strong SFB 1054 collaborative effort headed by Thomas Korn (B06) more
20.02.2024

Bioinformatics Day 2024

A Bioinformatics networking event on the Munich Life Science Campus more
06.02.2024

Niche-specific control of tissue function by regulatory T cells—Current challenges and perspectives for targeting metabolic disease.

Perspective report in Cell Metabolism from the Daniel lab (B11) more
20.01.2024 – 24.01.2024

The 4th Harald von Boehmer Midwinter Conference: Advances in Immunology

SFB 1054 International Symposium in Seefeld (Tyrol) more
09.01.2024

SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation

Bioscience Reports article from the Krappmann lab (A04) more
14.12.2023

Björn Clausen: Cracking the tubulin code of Langerhans cell and dendritic cell function

Institut für Molekulare Medizin, Universität Mainz more
07.12.2023 at 12:30

Christine Falk: The role of human tissue-resident T and NK cells for lung transplantation versus lung cancer

DZIF Braunschweig more
30.11.2023 at 12:30

Onur Boyman: Long-term allotransplant acceptance without immunosuppression

University Hospital Zürich more
28.11.2023

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.

SFB 1054 cooperation with the Heissmeyer, Ruland, Korn and Krappmann labs more
23.10.2023 – 26.10.2023

SFB 1054 Annual Meeting, October 23-26, 2023

The penultimate SFB Annual Meeting took place in the VIU facilities on San Servolo Island, Venice! more
12.10.2023

Biotech & Pharma Career Day 2023

Meet biotech and pharma companies from the greater Munich area more
21.09.2023

Immunoctoberfest Symposium 2023

Expert and early career talks followed by discussion with special Munich flair! Organizers Veit Buchholz and Dietmar Zehn more
20.09.2023

Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration

Cell Metabolism article from the Daniel Lab more
18.09.2023

PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma

Nature Cancer article from the Ruland lab (B01) more
09.08.2023 – 11.08.2023

IRTG 1054 Retreat 2023 at the Söllerhaus in the Kleinwalsertal

With team-building exercises in Good Scientific Practice, Graphical Project Abstracts and Visual Communication more
19.07.2023

Hybrid seminar: Emmanuel Saliba (University of Würzburg & Helmholtz Institute für RNA-based Infection Research)

International Immunology Seminars Jena 2023: Translational Immunology more
06.07.2023

Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans

Am J Hum Genet article with contribution from the Heissmeyer lab more
29.06.2023

The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells

Nature Communications article from the Heissmeyer Lab more
18.04.2023

Phosphatidylserine-positive extracellular vesicles boost effector CD8+ T cell responses during viral infection

PNAS article from the Brocker lab with collaboration from the Buchholz lab more
04.04.2023

Roquin-dependent gene regulation in immune-mediated diseases and future therapies

International Immunology review by Temsse Raj, Arlinda Negraschus and Vigo Heissmeyer more
31.03.2023

Daniel Krappmann is head of "Signaling and Translation" (SAT)

New Research Unit at Helmholtz Munich more
30.03.2023 – 31.03.2023

interact 2023 – Science & Translation

Register now to present your research, hear talks from big names in academia, industry and science communications! more
15.03.2023

Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy

Science Advances article from the Ruland lab (B01) more
24.01.2023

TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions

Frontiers in Immunology article from the Krappmann lab (A04) more
19.01.2023

Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions

Molecular Cell article – more structural insights from collaborative project including Katja Lammens more
05.01.2023

Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation

Nature Immunology article from the Zielinski Lab more
02.01.2023

Critical functions of N6-adenosine methylation of mRNAs in T cells

Article by Taku Ito-Kureha and Vigo Heissmeyer more
21.12.2022

The fusion oncogene VAV1-MYO1F triggers aberrant T-cell receptor signaling in vivo and drives peripheral T-cell lymphoma in mice

European Journal of Immunology article from the Ruland lab (B01) more
01.12.2022

Cognate microglia–T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology

Nature Immunoloy publication with participation from the Korn lab (B06) more
20.11.2022

Distinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID-19 and after yellow fever vaccination

Eur J Immunol article from the Krug lab with first author former IRTG member, Elena Winheim more
15.11.2022

Veit Hornung is a Highly Cited Researcher 2022

The Clarivate ranking lists those researchers in the fields of the Natural Sciences and Medicine whose publications are most frequently cited worldwide. more
07.11.2022

"More than just an emergency relief program"

LMU News release about support for Ukranian researchers in the Munich scientific community more
04.11.2022

Secondary infections rejuvenate the intestinal CD103+ tissue-resident memory T cell pool

Science Immunology article from the Zehn lab (B14) more
27.10.2022

Guidelines for mouse and human DC generation

With collaboration from the Krug lab more
20.10.2022 – 25.10.2022

10th International Conference on Autoimmunity: Mechanisms and Novel Treatments in Chania, Crete/Greece

Co-organized by Thomas Korn (B06), Melanie Greter and Jennifer Gommerman more
17.10.2022

CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota

Journal of Immunology article from the Krug and Brocker labs more
14.10.2022

Film: Picture a Scientist

Matinee viewing and informal discussion session at the BMC more
05.10.2022

Biotech Career Opportunities in Munich

Career orientation event at the BMC for early career scientists more
29.09.2022

Sustainable World 2022

Global Challenges for Life Scientists more
19.09.2022 – 23.09.2022

Bridging Innovation and Translation in T cell Immunotherapy

Immunoctoberfest 2022 in Raitenhaslach – TUM Lehrstuhl für Tierphysiologie und Immunologie more
17.09.2022

Mechanistic understanding of human SLFN11

New awesome structures from the Lammens lab (B02) more
17.09.2022

Combining precision oncology and immunotherapy by targeting the MALT1 protease

Journal for ImmunoTherapy of Cancer review article co-authored by Daniel Krappman (A04) more
25.08.2022

LSGN PhD Student GET-TOGETHER

Poster Session, Food, Drinks, Music more
19.08.2022

Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50

Short article in Molecular Cell with contribution from the Lammens lab (B02) more
17.08.2022

MYB orchestrates T cell exhaustion and response to checkpoint inhibition

Nature article from the Zehn (B14), Buchholz (B15) and Kallies labs more
12.08.2022

Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity

Science Immunology article from the Schober, Busch land Buchholz labs (B09, B15) more
05.08.2022

Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1

Science Advances article from the Krappmann lab (A04) more
03.08.2022 – 06.08.2022

IRTG retreat in San Servolo, Venice

Sharing science, scenic excursions and a spectacular venue made for a memorable retreat! more
25.07.2022

The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells

Nature Immunology article by Heissmeyer and colleagues more
22.07.2022

The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the TH17 lineage in humans

PNAS article from the Korn lab (B06) more
29.06.2022

Cytotoxic FCER1G(+) innate-like T cells: new potential for tumour immunotherapy

Research Highlight article from the Ruland lab (B01) more
16.06.2022

Ly6D + Siglec-H + precursors contribute to conventional dendritic cells via a Zbtb46 + Ly6D + intermediary stage

Milestone publication from the Korn (B06) and Krug (A06) labs with collaborators more
01.06.2022

IL-24 intrinsically regulates Th17 cell pathogenicity in mice

Journal of Experimental Medicine article from the Korn lab (B06) more
31.05.2022

Core Facility Flow Cytometry recognized for excellence in management and operations

International Society for Advancement of Cytometry (ISAC) Recognized Shared Resource Laboratory more
27.05.2022

'Stem-like' precursors are the fount to sustain persistent CD8 + T cell responses

Nature Immunology review from the Zehn lab (B14) more
03.05.2022 – 05.05.2022

SFB 1054 Annual Meeting 2022 in Bad Kohlgrub

Talks and posters presenting exciting developments in "Control and Plasticity of Cell Fate Decisions in the Immune System" more
21.03.2022

Solidarity and Support for Scientists

The SFB 1054 offers fellowships for doctoral and postdoctoral researchers displaced by the war in the Ukraine more
01.03.2022

Kilian Schober elected to the "Young Council" of the Bavarian Academy of Sciences
31.01.2022

A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells

Cellular and Molecular Life Sciences article from the Krappmann (A04) and Zielinski (B10) labs more
28.01.2022

Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential

Science Immunology article from the Zielinski lab (B10) more
17.01.2022

Structural and biochemical characterization of human Schlafen 5

Nucleic Acids Research paper from the Lammens lab (B02) more
09.12.2021 09:30 – 12:00

Webinar Full Spectrum Cytometry - Theory & Resources

For SFB 1054 members using or planning to use the Cytek Aurora for high-parameter analysis more
02.12.2021

Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients.

From the Labs of Thomas Brocker und Anne Krug (A06, B03) more
26.11.2021

Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation

Sci Immunol article from the Korn and Ruland labs (B01, B06) more
23.11.2021

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses

Vigo Heissmeyer (A03) and team discover how the interaction of Roquin-1 and Regnase-1 proteins controls immune cell activation more
12.11.2021

TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease

Sci. Immunol. publication from the Krappmann lab (A04), in cooperation with Heissmeyer and Rühland labs more
28.10.2021

Kilian Schober receives Robert Koch Foundation Post-Doctoral Award

Recognition for young scientists from the Robert-Koch-Stiftung more
06.10.2021

Impaired function and delayed regeneration of dendritic cells in COVID-19

COVID-19 research collaboration with Krug and Brocker labs more
23.09.2021

Molecular basis of human ATM kinase inhibition

Nature Structural & Molecular Biology publication with contribution from the Lammens lab more
22.09.2021

Georges-Köhler Prize 2021 awarded to Veit Buchholz
12.09.2021 – 26.09.2021

1st LSGN MEME ART CONTEST

And the winners are ... more
03.09.2021

Carolin Daniel receives the 2021 Isil Berat Barlan Award for Women Scholars in Immunology

Announced at the virtual European Congress of Immunology 2021 more
01.09.2021

Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation

Nature Communications publication from the Heissmeyer lab (A03) more
20.08.2021

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Collaboration with the Busch and Buchholz labs more
26.07.2021

Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping'

Nature Communications publication from Project B09 – Kilian Schober and Dirk Busch more
08.07.2021

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8+ T cells

JCI Insight article from the Zehn lab (B14) more
07.07.2021

CRC collaboration (B06, B09, B15) published in Nature Immunology

"Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity" more
11.05.2021

Bioimaging Day 2021

A successful event with wide outreach! more
23.04.2021

Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice

(A06 & B03) Publication in Brain, Behavior and Immunity more
22.04.2021

Veit Hornung awarded ERC Advanced Grant

Advanced Grant from the European Research Council for the study of pivotal components of the innate immune system more
24.03.2021

Publication Prize 2021 for Veit Buchholz

Else Kröner-Fresenius-Stiftung honors outstanding publications more
01.03.2021

Veit Buchholz awarded ERC Starting Grant
09.02.2021

Carolin Daniel (B11) receives the 2021 Research Award from the Heinz Bürger-Büsing Foundation

Recognition for research into mechanisms of immune tolerance in type 1 diabetes at an early age more
08.02.2021

Projects A06 Krug & B03 Brocker - new publication

Collaboration results in Gut Microbes report more
01.02.2021

The Ferdinand-Bertram-Prize awarded to Carolin Daniel

Sponsored by the Deutsche Diabetes Gesellschaft more
29.01.2021

Prof. Dr. Jürgen Ruland - Leibniz Prize Winner 2021

Prof. Jürgen Ruland is being honoured with the 2021 Leibniz Prize of the German Research Foundation (DFG). more
20.01.2021

Wie kommuniziert Wissenschaft?

Diskussion mit Beispielen aus der aktuellen Coronavirus-Forschung an der LMU more
11.01.2021

Responsible Research 2021

See the updated toolbox! more
01.12.2020

SFB 1054 funding continues!

We are pleased to announce that the CRC 1054 will be funded by the DFG for another four years! more
18.11.2020

Nucleic Acids Research publication from the Brocker Lab (B03)

Collaboration with the Helmholtz Zentrum AG Fabian Theis more
14.10.2020

Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia

J Exp Med article from the Ruland lab (B01) more
02.10.2020

Julia Matthias - award winner

Congratulations to Julia Matthias (AG Zielinski)! more
10.09.2020

Structural basis for sequestration and autoinhibition of cGAS by chromatin

Nature publication with contribution from Katja Lammens (B02) more
23.12.2019

New Instrument at the Core Facility!

the Cytek Aurora 5-laser has arrived! more
11.11.2019 – 13.11.2019

SFB 1054 Annual Meetings 2018-2019

in Bad Kohlgrub more
10.09.2019 – 13.09.2019

Joint Annual Meeting of the DGfI and the SIICA

International Symposium more
24.07.2019 – 26.07.2019

IRTG Retreat 2019
19.01.2019 – 23.01.2019

SFB 1054 International Symposium: 3rd Midwinter Conference – Advances in Immunobiology

"Cell-Fate Decisions of the Immune System" more
13.11.2018

Mini-Symposium on Single-Cell Genomics in Immunology
12.11.2018

Kathrin Schumann joins the SFB 1054 as associated member
12.10.2018

Regulation of lymphocyte responses by the tissue microenvironment

SFB 1054 International Symposium more
26.02.2018

Felix Meissner associated with SFB 1054
02.01.2017

Ludger Klein receives ERC Advanced Grant 2016
18.11.2016

2nd Funding Period Granted to the SFB1054!
02.03.2016

International Symposium: SFB 1054 Control and Plasticity of Cell-Fate Decisions in the Immune System
27.11.2015

Cellular and Molecular Regulation of Immunity in Barrier Organs

SFB 1054 International Gender Symposium more
22.10.2013

SFB 1054 Annual Meetings 2013-2015

San Servolo, Venice and Grainau, Badersee more

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