Niche-specific control of tissue function by regulatory T cells—Current challenges and perspectives for targeting metabolic disease.

Maike Becker, Sandra M. Dirschl, Martin G. Scherm, Isabelle Serr, Carolin Daniel (2024 Feb 6) Niche-specific control of tissue function by regulatory T cells—Current challenges and perspectives for targeting metabolic disease. Cell Metabolism 36(2) 229-239. https://doi.org/10.1016/j.cmet.2023.12.019 (Project B11)

Summary cited directly from the article:

Tissue regulatory T cells (Tregs) exert pivotal functions in both immune and metabolic regulation, maintaining local tissue homeostasis, integrity, and function. Accordingly, Tregs play a crucial role in controlling obesity-induced inflammation and supporting efficient muscle function and repair. Depending on the tissue context, Tregs are characterized by unique transcriptomes, growth, and survival factors and T cell receptor (TCR) repertoires. This functional specialization offers the potential to selectively target context-specific Treg populations, tailoring therapeutic strategies to specific niches, thereby minimizing potential side effects. Here, we discuss challenges and perspectives for niche-specific Treg targeting, which holds promise for highly efficient and precise medical interventions to combat metabolic disease.