Project A05 - Deciphering the role of the cyclin-dependent kinase (CDK) cascade in human immune cell plasticity – Insights from children with inflammatory bowel disease
Monogenic forms of very early onset inflammatory bowel disease (VEO-IBD) provide critical insights into key factors controlling human immune homeostasis. In this project, we will examine phenotypes of a monogenic disease affecting the cyclin-dependent kinase (CDK) cascade in patient-derived or CRISPR-engineered immune cells. Furthermore, we will employ humanized mice to analyze immune cell homeostasis in lymphoid and intestinal tissues and to monitor the development of colitis. We postulate that our studies on monogenic VEO-IBD will highlight basic mechanistic insights into the role of cyclin-dependent kinase (CDK) cascade in human immune cell plasticity and thus will have critical impact for several common autoimmune and inflammatory diseases.