SFB 1054 Seminar - Sarina Ravens
Centre for Laboratory Medicine, Institut of Immunology, Hannover Medical School, Germany
11.10.2018 at 12:15
Title: Understanding the functional adaptation of gamma delta T cells using next generation sequencing technologies
Depending on their ontogeny, anatomical localization and function γδ T cells express different γδ T-cell receptors (TCR), which are generated by the Rag-mediated V(D)J recombination of γ- and δ-gene segments in the thymus. While lower frequencies of γδ T cells are found in peripheral blood, specific γδ T cell subsets are highly enriched and maintained as long-living cells within tissues, while other populations display a high functional heterogeneity. We apply next generation sequencing technologies to understand (i) the functional adaptation of human γδ T cell receptor repertoires in response to viral infections at clonal level during early childhood, in adult healthy individuals and stem cell transplant recipients and (ii) how the maintenance and tissue-specific function of murine IL-17 producing γδ T cells is reflected at single-cell transcriptomes.
Venue:
BioMedical Center (BMC), Room N 01.017,
Großhaderner Str. 9, Planegg-Martinsried
Host: Ludger Klein (A01)
