SFB 1054 Seminar - Rose Zamoyska
Institute of Immunology and Infection Research, University of Edinburgh, UK
05.03.2018 at 17:00
Title: Autoimmunity versus anti-tumour Immunity: the flip sides of CD8 T cell responses
Activation and termination of immune responses are balanced through cross-talk between tyrosine kinases and phosphatases immediately downstream of the T cell receptor. Changes in expression and point mutations in these molecules, in particular the cytoplasmic phosphatase PTPN22, have been linked to autoimmunity. We have been asking how these mutations perturb homeostasis and result in a failure of regulation, and at what point do perturbations in the homeostatic balance of the immune system tip into immunopathology and autoimmunity. On the flip side, can we use these mutations to improve responses of T cells, particularly in the context of immunotherapy to cancer?
Venue:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (MIH), Raum 0.002, EG
Trogerstraße 30, 81675 München
Host: Dietmar Zehn (B14)
