SFB 1054 Seminar - Benoit Salomon
French National Institute of Health and Medical Research, Paris, France
16.11.2017 at 12:15
Title: Role of immune metabolism in Treg biology and function
Regulatory T (Treg) cells play a major role in the regulation of immune responses by limiting CD4+ and CD8+ conventional T cell activation. Cellular metabolism of conventional T cells has been intensely studied in recent years revealing, among other findings, that their activation requires a switch from AMPK to mTOR driven metabolic pathways. However, we know little about metabolism of Treg cells and the rare published data are quite controversial. Thus, we have investigated the role of AMPK (coded by Prkaa) and mTOR in Treg cells by generating mice that have a conditional knockout of these molecules specifically in Treg cells. Whereas the Foxp3cre x Prkaa1lox mice were healthy, the Foxp3cre x mTorlox mice developed a severe autoimmune syndrome. Our data showed that mTOR-deficient Treg cells displayed a defect of proliferation, suppressive function and stability. Our results reveal a new role of the AMPK/mTOR metabolic balance in Treg cell biology.
Venue:
BioMedical Center (BMC), Room N 01.017,
Großhaderner Str. 9, Planegg-Martinsried
Host: Reinhard Obst (B07)
