SFB 1054 Seminar - Matthew A. Williams
University of Utah, Salt Lake City, US
09.11.2017 at 12:15
Title: TCR-dependent differentiation of CD4+ memory T cells
Abstract: Following their activation in vivo, T cells undergo rapid proliferation and the acquisition of effector functions. After pathogen clearance, however, most effector T cells are fated to die, with only a small proportion surviving to form memory T cells. Polyclonal T cell responses are composed of diverse TCRs that play a key role in shaping T cell responses by controlling effector differentiation (i.e. Th1 vs. Th2, Th1 vs. Tfh). We recently reported an additional role for the TCR in guiding the differentiation of CD4+ memory T cells. This lecture will further explore the role of TCR signal strength in controlling effector vs. memory T cell fate decisions in vivo.
http://medicine.utah.edu/pathology/research/labs/matthew-williams/
Venue:
BioMedical Center (BMC), Room N 01.017,
Großhaderner Str. 9, Planegg-Martinsried
Host: Dietmar Zehn (B14)
