SFB 1054 Seminar - Roxane Tussiwand
University of Basel, Switzerland
01.06.2017 at 12:15
Title: Dendritic Cells: from development to function
Dendritic cells (DCs) are critical regulators of the immune system bridging innate with adaptive immunity and maintaining tolerance. They are an immune subset dedicated to patrolling epithelial tissues and to responding to infections and sterile inflammation. Through the secretion of the appropriate cytokines and the initiation of the adaptive immune response, DCs are able to orchestrate immunity. The complexity of the different immune responses argues for subset specialization within the DC compartment. Understanding the functional identity of the different DC subsets is instrumental to understand how our immune system works. DC can be subdivided into 4 major branches: plasmacytoid DC (pDCs), monocyte derived DCs (moDC) and conventional dendritic cells type 1 (cDC1) and Type 2 (cDC2). Each DC lineage requires a specific transcriptional network for its development and its function. My research has mostly focused on defining the Irf8-Irf4 transcriptional modules actin during conventional DC development. Collectively, the study of the transcriptional regulation of the different DC subsets in the context of infections enables us to define the molecular clues required to trigger the necessary immune response. Further, understanding the pathways inducing protective immunity against pathogens and tumors will be instrumental for the discovery of novel targets aimed at modulating immune responses in chronic inflammation as well as design targets for immune-based therapies.
Venue:
BioMedical Center (BMC) - Room N 01.017
Großhaderner Str. 9, Planegg-Martinsried
Host: Anne Krug (A06)
