SFB 1054 Seminar - Chandrashekhar Pasare
University of Texas Southwestern Medical Center, Dallas, USA
08.06.2017 at 12:15
Title: Innate mechanisms of regulation of memory T cell functions
Pathogen recognition by DCs via activation of pattern recognition receptors results in the up-regulation of MHC and co-stimulatory molecules and secretion of pro-inflammatory cytokines. While naive CD4 T cells require all three of these signals from DCs for successful activation and differentiation, MHC-TCR interaction is thought to be sufficient for memory CD4 T cell reactivation. Surprisingly, we find that reactivation of memory CD4 T cells via TCR and costimulatory molecule engagement is less optimal when compared to reactivation in the presence of dendritic cells suggesting that additional innate signals are necessary for fully functional effector CD4 T cells. Further investigation revealed a requirement for a specific group of cytokines, that we call “Licensing Cytokines” for optimal functioning of effector CD4 T cells in the secondary lymphoid organs as well as tissue resident memory CD$ T cells. The licensing cytokines are made by dendritic cells and play a critical role in regulating effector function of T helper lineage cells that extend beyond the requirement for MHC-TCR interactions. Our studies point to a novel innate controlled regulation of memory T cell function and warrants revisiting the currently established paradigm for effector and tissue resident memory CD4 T cell reactivation. The nature of the licensing cytokines and the mechanisms by which they regulate effector T cell functions will be discussed.
Venue:
BioMedical Center (BMC), Room N 01.017,
Großhaderner Str. 9, Planegg-Martinsried
Host: Anne Krug (A06)
