SFB 1054 Seminar - René A.W. van Lier
Sanquin Blood Supply Foundation, Amsterdam, The Netherlands
27.04.2017 at 17:00
Title: Blood and Beyond: properties of human tissue-resident T cells
Protection against respiratory infections in the lung is mediated by tissue-resident memory T-cells (TRM). We characterized memory T-cells from human lungs through transcriptome and functional analyses and revealed the existence of two distinct, but related memory T-cell populations in lung tissue. We discovered two transcriptional pathways that play essential roles the maintenance of TRM in tissue: one under the influence of NOTCH signaling1 and a second one controlled by the homologous transcriptional repressor BLIMP-1 and HOBIT2. Further, consistent with a requirement for prompt responsiveness to prevent microbial colonization of the respiratory barrier tissue, lung TRM constitutively transcribe deployment ready mRNAs encoding effector molecules and produce effector proteins with accelerated kinetics in response to TCR activation.
1 Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells. Hombrink P, Helbig C, Backer RA, Piet B, Oja AE, Stark R, Brasser G, Jongejan A, Jonkers RE, Nota B, Basak O, Clevers HC, Moerland PD, Amsen D, van Lier RA. Nat Immunol. 2016 Dec;17:1467-1478.
2 Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Mackay LK, Minnich M, Kragten NA, Liao Y, Nota B, Seillet C, Zaid A, Man K, Preston S, Freestone D, Braun A, Wynne-Jones E, Behr FM, Stark R, Pellicci DG, Godfrey DI, Belz GT, Pellegrini M, Gebhardt T, Busslinger M, Shi W, Carbone FR, van Lier RA, Kallies A, van Gisbergen KP. Science. 2016;352:459-63
Venue:
BioMedical Center (BMC), Room N 01.017,
Großhaderner Str. 9, Planegg-Martinsried
Host: Christina Zielinski (B10)
