SFB 1054 Seminar - Luís Graça
Instituto de Medicina Molecular, University of Lisbon, Portugal
23.05.2019 at 12:15
Title: Tissue adaptation of follicular T cells
It has long been known that CD4 T cells are necessary to provide help to B cells, triggering a germinal center (GC) reaction where affinity maturation and isotype switching occurs. However, the nature of the dedicated CD4 helper T cells, known as T follicular helper (Tfh), was only recently described. A population of Foxp3+ regulatory cells with unique access to the follicle – T follicular regulatory (Tfr) cells – represent the counterpart of Tfh cells. We found Tfr cells develop primarily from thymic Treg cells, retaining a TCR repertoire more similar to Treg cells than to the repertoire of Tfh cells from the same GC. In addition, human circulating Tfr cells represent an immature Tfr pool that emerges during ongoing humoral responses. We found, comparing different human lymphoid tissues, that Tfh and Tfr cells undergo progressive adaptation to different tissues. Furthermore, distinct Tfh and Tfr subsets emerge during the course of human autoimmune pathology, offering the possibility of a new strategy for disease stratification.
Venue:
BioMedical Center (BMC), Room N 01.017,
Großhaderner Str. 9, Planegg-Martinsried
Host: Dirk Baumjohann (B 12)
If you wish to meet with the speaker, please contact Katharina.Frank@med.uni-muenchen.de
