Kathrin Schumann joins the SFB 1054 as associated member
12.11.2018
Associated Project (Kathrin Schumann) - CRISPR-dissection of human regulatory T cell induction
Induced human Tregs (iTregs) could be potentially a cell source for immune therapies, but our knowledge how iTreg differentiation is regulated is still scarce. With CRISPR DNA editing we have now for the first time the possibility to genetically dissect these processes in vitro in human iTregs. This project aims to apply CRISPR screens to identify transcriptional circuits that regulate iTreg induction and stability.
Emmy Noether group leader
Institute for Clinical Neuroimmunology at BMC
Barbara Schraml will be associated with SFB 914 "Trafficking of Immune Cells in Inflammation, Development and Disease” starting on March 1, 2015. Funded by the Emmy Noether program of the German Research Foundation, Barbara Schraml has recently established her research group at the Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München. Her research focuses on understanding the ontogeny and function of dendritic cells in organ-specific immune responses.
In May 2018, Anneli Peters joined the SFB 1054 as associated member. Her research poject will focus on
Cellular sources and impact of the cytokine IL-23 for differentiation of pathogenic Th17 cells
Differentiation of stable Th17 cells with pathogenic effector functions in the context of autoimmunity requires the presence of Interleukin-23 (IL-23), and lack of IL-23 is protective in several autoimmune diseases. However, the cellular sources and stimuli of IL-23 production are not well understood. Utilizing a reporter mouse model we aim to identify cell types that produce IL-23 during development and progression of CNS autoimmunity and demonstrate the relevance of cell-type specific IL-23 production for the development of stable pathogenic Th17 cells via conditional deletion.
Contact:
Dr. Anneli Peters
BioMedical Center (BMC)
Ludwig-Maximilians-Universität München
Großhaderner Str. 9
82152 Planegg-Martinsried
Germany
Email: Anneli.Peters(at)med.uni-muenchen.de
Homepage:
http://www.klinikum.uni-muenchen.de/Institut-fuer-Klinische-Neuroimmunologie/en/forschung/ag_peters/labor/index.html