Felix Meissner associated with SFB 1054

Associated Project (Felix Meissner) - Dissecting CD4+ T helper cell heterogeneity and phenotype with quantitative proteomics

CD4+ T helper (Th) cells orchestrate protective immunity by producing paracrine signals that regulate B and T cells. Due to technical limitations in studying intercellular crosstalk comprehensively, however, it remains largely unexplored, how diverse Th cell-derived paracrine signals are and which functions arise from differential sets of released proteins with known and not yet described functions. This project aims at establishing a system-level view of Th cell heterogeneity based on quantitative proteomics of secreted proteins and will generate new hypotheses about how paracrine signals define Th cell phenotype and function.

 

 

Emmy Noether group leader

Institute for Clinical Neuroimmunology at BMC

 Barbara Schraml will be associated with SFB 914 "Trafficking of Immune Cells in Inflammation, Development and Disease” starting on March 1, 2015. Funded by the Emmy Noether program of the German Research Foundation, Barbara Schraml has recently established her research group at the Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München. Her research focuses on understanding the ontogeny and function of dendritic cells in organ-specific immune responses.

 

In May 2018, Anneli Peters joined the SFB 1054 as associated member. Her research poject will focus on

Cellular sources and impact of the cytokine IL-23 for differentiation of pathogenic Th17 cells

Differentiation of stable Th17 cells with pathogenic effector functions in the context of autoimmunity requires the presence of Interleukin-23 (IL-23), and lack of IL-23 is protective in several autoimmune diseases. However, the cellular sources and stimuli of IL-23 production are not well understood. Utilizing a reporter mouse model we aim to identify cell types that produce IL-23 during development and progression of CNS autoimmunity and demonstrate the relevance of cell-type specific IL-23 production for the development of stable pathogenic Th17 cells via conditional deletion.

 

Contact:

Dr. Anneli Peters
BioMedical Center (BMC)
Ludwig-Maximilians-Universität München
Großhaderner Str. 9
82152 Planegg-Martinsried
Germany
Email: Anneli.Peters(at)med.uni-muenchen.de

 

Homepage:

http://www.klinikum.uni-muenchen.de/Institut-fuer-Klinische-Neuroimmunologie/en/forschung/ag_peters/labor/index.html