SFB 1054 Seminar - Jean Pieters
Title: A pathway towards tolerance: How to accept ‘self’ while fighting ‘foreign’
Our laboratory is investigating the mechanisms that are involved in immune cell activation upon triggering by diverse stimuli. Among the contributions of the laboratory to a better understanding of immunity are the characterization of the intracellular events leading to antigen presentation, the identification of immune evasion mechanisms employed by the human pathogen Mycobacterium tuberculosis within macrophages and the discovery of a leukocyte specific signaling pathway essential for T cell survival. One long-standing interest has been to decipher the role of the immunoregulatory protein coronin 1 in T cell biology. Our recent work suggests the presence of a signaling pathway that is specifically involved in allo- and autoimmune reactions while being dispensable for anti-pathogen immunity. Targeting of this pathway may allow the control of allo-and autoimmunity while not compromising immune defense against infectious diseases. In my seminar, I will discuss the background of these findings as well as our recent results and talk about potential implications of this work.
Host: Reinhard Obst (B07)
If you wish to talk to the speaker, please contact Katharina Frank