SFB 1054 Seminar - Manfred B. Lutz
Title: Signals directing monocytes towards myeloid-derived suppressor cell or dendritic cell differentiation
Monocytic cells are continuously released from the bone marrow during steady state and present at relatively constant numbers in the circulation. Their production in the bone marrow is strongly increased upon inflammatory signals. GM-CSF represents a prototype cytokine for mediating the myeloid precursor cell proliferation during such emergency myelopoiesis conditions. Monocyte generation and release from the bone marrow is increased. We and others have shown that GM-CSF promotes both the generation of immuno-stimulatory monocyte-derived dendritic cells (DCs) but also immunosuppressive monocytic myeloid derived suppressor cells (MDSCs). We dissected the signaling pathways of GM-CSF in monocytes which allowed us to generate a model to understand the functionally divergent differentiation opportunities of monocytes.
Host: Anne Krug (B03)