SFB 1054 Seminar - Christopher Allen
Title: Control of IgE antibody responses by intrinsic and extrinsic mechanisms
IgE antibodies may elicit potent allergic inflammatory responses and thus their production is tightly regulated. We have developed novel approaches to directly study the genesis of IgE-expressing B cells and their differentiation into IgE-secreting plasma cells. Our work has revealed both intrinsic and extrinsic mechanisms of the regulation of IgE responses. We found that IgE responses are strongly influenced by B cell receptor signaling and we identified unique features of the IgE B cell receptor that promote rapid plasma cell differentiation. We also determined that IgE-expressing B cells in germinal centers exhibit reduced antigen uptake and presentation as well as elongated cell cycles, limiting the extent of affinity maturation of the IgE response. Finally, we have characterized the role of adjuvants and cytokines in the regulation of IgE class switch recombination. Our findings have important implications for understanding the control of IgE responses.
Host: Dirk Baumjohann (B12)