Critical functions of N6-adenosine methylation of mRNAs in T cells
Article by Taku Ito-Kureha and Vigo Heissmeyer
02.01.2023
Ito-Kureha T, Heissmeyer V (2023 Jan) Critical functions of N6-adenosine methylation of mRNAs in T cells. Biochim Biophys Acta Mol Cell Res. 1870(1):119380. doi: 10.1016/j.bbamcr.2022.119380.
Abstract cited directly from the article:
The existence of N6-adenosine methylation (m6A) of mRNA has been known for a long time, but only recently its regulatory potential was uncovered. Current research deciphers the molecular determinants leading to the deposition of this modification and consequences for modified mRNAs. It also evaluates the importance of such modifications for specific cell types and programs. In this review, we summarize the current knowledge on m6A modification of mRNAs in conventional and regulatory T cells and T-cell-driven immune responses and pathology. We discuss the impact of m6A modification on T cell activation including cytokine and antigen receptor signaling or sensing of double-stranded RNAs (dsRNA).
